Renal Artery Stenosis
Conditions
Keywords
renal artery stenosis, renal perfusion
Brief summary
The clinical benefits of endovascular treatment in renal artery stenosis remain controversial. This study uses arterial spin labelling MRI and flat-panel detector parenchymal blood volume imaging to observe the change in renal perfusion after endovascular treatment in renal artery stenosis.
Interventions
None listed
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* patients who provided informed consent * patients who were diagnosed with RAS by CTA, MRA, or Doppler ultrasonography * patients who were aged 18 years or older * patients whose intervened renal arteries were not completely occluded (confirmed by DSA) * the stenosis percentage exceeding 70% * patients who had uncontrolled blood pressure or impaired renal function * paitents whose affected kidney did not have total loss of function
Exclusion criteria
* were pregnant * had a history of renal transplantation or renal artery bypass surgery * were allergic to iodine contrast medium * had other contraindications of endovascular treatment * contraindications of MRI examinations * had technical failure in the endovascular treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perfusion of the target kidney assessed by Arterial Spin Labelling MRI | Changes from baseline renal perfusion at 2 months |
| Perfusion of the target kidney assessed by Flat-panel Detector Parenchymal Blood Volume Imaging | Changes from baseline renal perfusion immediately after endovascular intervention |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure | Changes from baseline blood pressure at 1 year |
| Renal function | Changes from baseline renal function at 1 year |
Countries
China
Contacts
Primary ContactBao Liu
Outcome results
None listed