Are Sporadic Colorectal Cancers in Young Distinct From Elderly?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05601609

Enrollment

1599

Registered

2022-11-01

Start date

2020-11-11

Completion date

2022-08-02

Last updated

2022-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Neoplasms

Keywords

young colorectal cancer patients, elderly colorectal cancer patients, sporadic colorectal cancer

Brief summary

In this study, the investigators compared and evaluated the clinicopathological and oncological characteristics of sporadic colorectal cancer (CRC) in young adults without genetic mutations associated with hereditary CRC syndrome and sporadic CRC in elderly individuals.

Detailed description

The ambiguity in the findings among several previous studies might be because of the difference in the age of the study population, yCRC and eCRC. The family history of CRC and cancer due to Crohn's disease or ulcerative colitis were also not excluded in such previous studies. Most importantly, those studies did not rule out the risk of hereditary cancer through the genetic testing in yCRC. Since hereditary CRC accounts for approximately 34% of those under the age of 35 years, it is necessary to exclude it to accurately compare the clinicopathological characteristics of sporadic cancer developed in yCRC and eCRC.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Inclusion criteria

* Histologically confirmed cases of adenocarcinoma in the colon and rectum * The age at the time of diagnosis should be ≤ 40 years (for yCRC) or ≥ 70 years (for eCRC) * Genetic testing confirmation of non-hereditary cancer.

Exclusion criteria

* Inflammatory bowel disease * A family history of CRC * A history of other cancers * Underwent any emergency operation or palliative surgery * The Amsterdam criteria with mutations in genes associated with APC, MLH1, MSH2, MSH6

Design outcomes

Primary

Measure	Time frame	Description
Overall survival outcome in young colorectal cancer (yCRC) and elderly colorectal cancer (eCRC)	The OS was defined as the time period from the date of surgery to the date of death or last follow-up up to 3 years	The 3-year overall survival (OS) in yCRC and eCRC

Secondary

Measure	Time frame	Description
Cancer-specific survival outcome in young colorectal cancer (yCRC) and elderly colorectal cancer (eCRC)	CSS was defined as the time period from the date of surgery to the date of death from CRC up to 3years	The 3-year cancer-specific survival (CSS) in yCRC and eCRC

Countries

South Korea

Outcome results