Healthy
Conditions
Keywords
Metabolome, Pork, Metabolite
Brief summary
The purpose of the research is to assess the dose-dependent impacts of the consumption of fresh pork on blood-borne metabolites (markers) following the controlled feeding of pork
Detailed description
Eligible participants will follow 3 randomly ordered 4-week feeding periods varying only with the consumption of 0, 3 or 6 oz of pork or a 50:50 blend of chicken and beef (6, 3 and 0 oz for respective trials to ensure similar total poultry/meat intake among trials).
Interventions
DIETARY_SUPPLEMENTPork Consumption
Feeding of pork is controlled at 0, 3 or 6 oz per day for 4 weeks each in random order.
Sponsors
San Diego State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SCREENING
Masking
NONE
Intervention model description
3 conditions, order randomly allocated
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* generally healthy (i.e., an absence of diagnosed chronic illnesses and inborn metabolic disorders) * Age 18-65 * all races * both sexes * willingness to comply with the research diet requirements
Exclusion criteria
* special dietary needs (e.g., vegetarianism, gluten-free, etc.) * use of medication known to influence metabolism * smoking * substance use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metabolic biomarker discovery | 4 weeks | Biomolecules detected through metabolomic profiling that will result in discovery of a metabolic signature for pork intake |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Triglycerides | 4 weeks | Triglycerides |
| Interleukin-6 | 4 weeks | Interleukin-6 |
| Fasted Glucose | 4 weeks | Fasted Glucose |
| Insulin | 4 weeks | Insulin |
| LDL-Cholesterol | 4 weeks | LDL-Cholesterol |
| Total Cholesterol | 4 weeks | Total Cholesterol |
| C-Reactive Protein | 4 weeks | C-Reactive Protein |
| Blood Pressure | 4 weeks | Systolic and Diastolic |
| Body Composition | 4 weeks | Weight measured via scalre, body fat% muscle mass as measured via DEXA |
| HDL Cholesterol | 4 weeks | HDL Cholesterol |
Countries
United States
Outcome results
None listed