The Effectiveness of Single Antibiotic Paste Nitrofurantoin Versus Double Antibiotic Paste

The Effectiveness of Single Antibiotic Paste Nitrofurantoin V/S Double Antibiotic Paste in Alleviation of Post-Operative Pain in Adult Patients Symptomatic Irreversible Pulpitis

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05600023

Enrollment

Registered

2022-10-31

Start date

2022-08-01

Completion date

2022-10-24

Last updated

2022-10-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Symptomatic Irreversible Pulpitis

Brief summary

In our study, we used nitrofurantoin as a root canal medication in patients suffering from symptomatic irreversible pulpitis in alleviating pain compared with double antibiotic paste.

Detailed description

This study aims to compare the efficacy in alleviating pain between intracanal medicaments Nitrofurantoin versus double antibiotic paste.

Interventions

DRUGNitrofurantoin

Nitrofurantoin has been found to successfully eradicate gram-negative bacteria such as Enterococcus faecalis that one of the most important bacteria in endodontic lesions

DRUGDouble Antibiotic

DAP is a combination of two antibiotics which are ciprofloxacin and metronidazole

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* No medical history * no history of allergy to medications used in root canal treatment * patients suffering from Symptomatic Irreversible Pulpitis

Exclusion criteria

* Patients who were not suitable for conventional root canal treatment * multirooted teeth

Design outcomes

Primary

Measure	Time frame	Description
To alleviate dental pain	12 hours upto 72 hours following placement of intracanal medicament	Dental pain will be measured by using Visual Analogue Scale(VAS) which is an 10-point scale from 0-10 where 0 represents no pain and 10 represents the worst pain measured

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026