Alzheimer Disease
Conditions
Brief summary
Modifying health behaviors like physical activity level, diet, stress, and mental activity level can lower risk for Alzheimer's disease, but many middle-aged and older adults find it difficult to sustain health behavior changes over the long term. This project will develop a new intervention that educates people about Alzheimer's disease risk factors and helps them understand how their personal health beliefs may prevent them from making long-lasting lifestyle changes. The goal is to help people sustain health behavior changes to prevent or delay the onset of Alzheimer's disease and related dementias.
Interventions
BEHAVIORALEnhanced Healthy Living Education
24-session healthy living education program, with enhanced content about health beliefs and mechanisms of behavior change
BEHAVIORALBasic Healthy Living Education
24-session healthy living education program
Sponsors
Rhode Island Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
45 Years to 69 Years
Healthy volunteers
Yes
Inclusion criteria
* age 45-69 years * normal cognition (Minnesota Cognitive Acuity Scale \> 52) * English language fluency * at least two of the following: i) BMI \> 24.9; ii) systolic blood pressure \> 125 mmHg; iii) LDL cholesterol \> 115 mg/dL; iv) HbA1C \> 6.0%; v) at least one APOE ε4 allele; vi) first-degree relative with AD.
Exclusion criteria
* history of serious mental illness (i.e., schizophrenia, bipolar disorder) * history of neurologic or neurodevelopmental disorder * current alcohol or drug use disorder based on self-report * current enrollment in an AD prevention clinical trial.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Perceived Threat of Alzheimer's Disease Scale | baseline | 7-item Likert-type scale assessing perceived likelihood, concern, and consequences of Alzheimer's disease; higher scores indicate greater perceived threat |
| Dementia Awareness Questionnaire | baseline | self-report measure of knowledge of modifiable Alzheimer's disease risk factors; higher scores are associated with greater dementia awareness |
| Generalized Self-Efficacy Scale | baseline | 10-item self-report questionnaire assessing belief in one's own abilities; higher scores indicate greater self-efficacy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Perceived Stress Scale | baseline | 10-item measure that assesses perceived stress; higher scores indicate greater perceived stress |
| Mediterranean Diet Assessment Tool | baseline | 14-item measure of adherence to a Mediterranean type diet; higher scores indicate greater diet adherence |
| Positive and Negative Affect Schedule | baseline | 20-item measure that assesses positive and negative emotional experiences, yielding two scores; higher scores indicate greater experience of positive or negative experiences, respectively |
| CHAMPS Activities Questionnaire for Older Adults | baseline | self-report measure of engagement in physical activities, tailored to older adult population; higher scores indicate greater engagement in physical activity |
| Florida Cognitive Activities Scale | baseline | 25-item self-report measure about engagement in mentally stimulating activities; higher scores indicate greater cognitive activity |
Countries
United States
Contacts
Primary ContactLaura Korthauer, PhD
Outcome results
None listed