Celiac Disease, Dermatitis Herpetiformis
Conditions
Keywords
coeliac disease, dermatitis herpetiformis, gluten-free diet, transglutaminase, microbiata
Brief summary
The main purpose of this study is to investigate genetic, serological, immunological and microbiata diversities between different coeliac disease phenotypes and to discover applicable prognostic markers for specific phenotypes.
Detailed description
The recognition of clinical heterogeneity has expanded the understanding of coeliac disease, but the factors contributing to this diversity remain unclear. Moreover, since coeliac disease is highly heterogeneous, there is a need for more individualized follow-up and support and implementation of more personalized follow-up guidelines. In this study coeliac disease and dermatitis herpetiformis patients and healthy controls will be recruited. Genetic, clinical, immunological, micobiata and novel biomedical markers are compared between coeliac disease phenotypes and also controls and their prognostic value is assessed.
Interventions
GENETICGenetic predisposition
Assessment of genetic predisposition to various celiac disease phenotypes. No intervention.
Sponsors
Tampere University
University of Helsinki
University of Turku
Oulu University Hospital
University of Debrecen
University of Trieste
Oslo University Hospital
Tampere University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Cohorts 1 and 2: coeliac disease or dermatitis herpetiformis diagnosis * Cohort 3: friend or non-related family member of coeliac disease or dermatitis herpetiformis patient
Exclusion criteria
* Cohorts 1-3: Age \<18 years * Cohorts 1 and 2: coeliac disease or dermatitis herpetiformis diagnosis not confirmed * Cohort 3: coeliac disease or dermatitis herpetiformis diagnosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Non-HLA variant association | baseline | phenotype specific non-HLA variants |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| serum transglutaminase antibodies | baseline | Levels of serum antibodies against transglutaminase |
| microbiata | baseline | skin and intestinal microbiata findings |
| quality of life measure | baseline | PGWB questionnaire (22-items with values 1-6, total score range 22-132, a higher score indicating better quality of life) |
| gastrointestinal symptoms | baseline | GSRS-questionnaire (15 items with values 1-7, total score 1-7 as a mean value of all scores, higher score indicating more severe symptoms) |
| dietary adherence | baseline | strictness of gluten-free diet (GIP-test) |
Countries
Finland
Contacts
Primary ContactTeea T Salmi, Prof
Outcome results
None listed