Cognitive Impairment, Psychotic Disorders
Conditions
Keywords
Schizophrenia, Affective Disorders, IQ Tests, Psychotic Disorders, Cognition
Brief summary
Patients with Psychotic disorders (Schizophrenia, Bipolar disorder and Schizoaffective disorder) often suffer from significant cognitive impairments, however how these develop and change over time before and after the first psychotic break is unclear. While there are data by several groups, showing that many future patients have significant cognitive impairments years before the onset of psychosis, many future patients seem to be doing well before the manifestation of psychosis, and decline steeply in functioning after their first psychotic episode. Hence the timing of the onset of cognitive impairment in patients with psychotic disorders requires further exploration. The current study will investigate the timing of cognitive impairment by using IQ tests before and after the first psychotic break
Detailed description
In this study the investigators aim to use the DAPAR tests (A cognitive assessment which all 17 year old Jewish adolescents in Israel undergo to participate in mandatory military service), which measures intelligence, and is equivalent to the IQ test. The subjects will be persons who had their first psychotic break, at least one year following the DAPAR tests. As part of the study, the participants will re-take the DAPAR tests, after the onset of the psychotic illness.
Interventions
DIAGNOSTIC_TESTDAPAR Tests (IQ equivalent test)
This study will compare DAPAR scores before and after the onset of the psychotic illness.
Sponsors
Sheba Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
- Study Group: * Patients between the ages 27-18 who had first psychotic break in the last ten years, and more than a year from the date of the DAPAR tests. * Diagnoses of schizophrenia, Bipolar disorder or Schizoaffective disorder according to DSM-5 criteria. * Previous DAPAR tests at the age of 17. Inclusion Criteria - Control group: * Participants between the ages of 27-18. * No history of psychotic break. * Previous DAPAR tests at the age of 17.
Exclusion criteria
- Both groups: * Participants who did not perform the full battery of the DAPAR tests. * Participants who have been appointed a guardian.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in DAPAR (An Israeli cognitive test) scores | 1 day (During recruitment visit) | Cognitive changes in both groups (lowest 10 - highest 90) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Psychotic Symptoms | 1 day (During recruitment visit) | PANSS-6 (Positive and Negative Syndrome Scale - Abbrevieted) scores (lowest 0- highest 36) |
| Social Functioning | 1 day (During recruitment visit) | PSP (Personal and Social Performance Scale) Scores (lowest 0- highest 100) |
| Cognitive Functioning | 1 day (During recruitment visit) | WAIS-III (Wechsler Adult Intelligence Scale) (4 specific sub-tests) |
| Coping strategies | 1 day (During recruitment visit) | COPE (Assessing Coping Strategies) scores (lowest 0 - highest 90) |
Countries
Israel
Contacts
Primary ContactNoaz Cohen, MA
Outcome results
None listed