Bone Metastases, Urogenital Cancer
Conditions
Keywords
Bone scintigraphy
Brief summary
The study aims to compare the diagnostic performance of planar bone scan and two bed SPECT/CT in detection of bone metastases in patients with urogenital cancer.
Detailed description
Genitourinary malignancies represent a heterogeneous group of diseases linked by anatomical and physiological function. Renal cell carcinoma (RCC); urothelial carcinoma of the bladder, ureter, and renal pelvis, and prostate adenocarcinoma (PC) are the most commonly encountered histological subtypes within this group. Planar bone scintigraphy (PBS) with di-phosphonate compounds is widely used, cost-effective and sensitive imaging modality for detecting osseous metastases especially in prostate cancer. However, it suffers from low specificity as well as low sensitivity in purely osteolytic lesions. Single-photon emission computed tomography (SPECT) is a three-dimensional acquisition method that has demonstrated greater sensitivity and specificity compared to planar images, especially for detecting vertebral metastases. The introduction of SPECT/CT images improves the lesion-to-background ratio, allows anatomic lesion localization, removes the superimposition of anatomical structures, such as urinary bladder activity, and provides anatomical data, thereby increasing the sensitivity, specificity and positive predictive value of bone scan. As the technology advances, current SPECT/CT machines have become capable of sequentially covering, and accurately merging, more than one field of view (FOV) in a reasonable time. In this study, we aim to compare the diagnostic performance of two-bed SPECT/CT images and planar bone scintigraphy in detection of bone metastases in genitourinary malignancies.
Interventions
RADIATIONTc-99m MDP and gamma camera
Injection of radioactive element (Tc-99m MDP) then imaging with gamma camera and low dose CT (SPECT/CT)
Sponsors
Assiut University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients with urogenital cancer referred for bone scan.
Exclusion criteria
* Patients with claustrophobia. * Patients refuse to do the scan. * Patients with relative or absolute contraindications to do the scan (eg. pregnancy).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of diagnostic performance indices between two-bed SPECT/CT images and planar bone scans. | through study completion, an average of 2 years | Analysis and comparison of diagnostic performance indices between two-bed SPECT/CT images and planar bone scans for the detection of osseous metastases in genitourinary malignancies. |
Secondary
| Measure | Time frame |
|---|---|
| Identification of patients' subgroups who might be best assessed upfront by two-bed SPECT/CT. | through study completion, an average of 2 years |
| Identification of anatomical site which may be best assessed by SPECT/CT. | through study completion, an average of 2 years |
Contacts
Primary ContactMaram M Shafeek, Resident
Outcome results
None listed