Sepsis
Conditions
Keywords
sepsis, eNOS, NLR, PLR, Channa striata, albumin, inflammation, anti-oxidant
Brief summary
Sepsis is an inflammation response produced by the host's immune system, which is agrravated by oxidative stress. One of the adjuvant therapy according to Surviving Sepsis Campaign Guideline is albumin, which has anti-inflammatory and anti-oxidant effects. However, human albumin is quite expensive, and other forms with similar potency and less costs are needed, one of which is Channa striata extract. Therefore, this study is conducted to compare albumin and human albumin, specifically their anti- inflammatory and anti-oxidant properties by assessing the eNOS marker, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patient with sepsis.
Detailed description
In summary, this study showed that Channa striata extract has a better outcome in stabilizing eNOS level in patient with sepsis than human albumin 20%, and it has a potential benefit in stabilizing NLR values. However, further studies with a larger sample and a more advanced phase of sepsis are needed.
Interventions
DIETARY_SUPPLEMENTAlbumin Channa Striata Extract
This study is a randomized controlled trial of 42 patients at the ICU of Dr. Moewardi General Hospital. The control group received 20 grams of human albumin on the first day and the study group received 15 grams of Channa striata extract daily for two days. Subsequently, eNOS, NLR and PLR are measured before and three days after treatment, and the examiners compare the three markers statistically.
Sponsors
Universitas Sebelas Maret
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients sepsis who met the qSOFA criteria ≧ 2 \[two of which: unconsciousness (Glasgow Coma Scale ≤14) * respiratory rate \> 22 and systolic blood pressure ≤ 100 mmHg\], * aged ≧ 18 years * admitted to intensive care unit and high care unit at Dr. Moewardi General Hospital
Exclusion criteria
* patients with severe trauma * blood loss in stage three or higher * stress ulcers * a history of nephrotic syndrome * refusal to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endothelial Nitric Oxide Synthase | three days after treatment | Measured before and three days after treatment, and the examiners compare the three markers statistically. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neutrophil-Lymphocyte Ratio | three days after treatment | Measured before and three days after treatment, and the examiners compare the three markers statistically |
| Platelet-Lymphocyte Ratio | three days after treatment | Measured before and three days after treatment, and the examiners compare the three markers statistically |
Countries
Indonesia
Outcome results
None listed