Autism Spectrum Disorder
Conditions
Brief summary
The goal of this observational study is to identify behavioral and physiological markers of social alterations in Autism Spectrum Disorders compared to Typically Developping peers. This single-centre study plan to use eye tracking to evaluate social disorders in Autism Spectrum Disorders (ASD). The investigators will estimate oculometric and pupillometric indices as potential ASD biomarkers. The study will last 4 years and will be organized in two phases.
Detailed description
In a first phase (expected to last 12-16 months), after an experimental validation in typical adults, relevant oculometric and pupillometric indices will be identified in a typical population of children and in a clinically diagnosed population of ASD children. In a second phase of the protocol (expected to last 32-36 months), biomarkers identified in the first phase will be tested on a larger population including other neurodevelopmental disorders.
Interventions
OTHEReye-tracker
Eye-tracker recordings of eye movements, gaze direction and pupillary reactivity
Sponsors
University Hospital, Tours
UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Laboratory of Fundamental and Applied Computer Science of Tours, EA6300
National Research Agency, France
Ministry of Health, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Days to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Phase 1 All groups have these 2 criteria in common: Free, informed and signed consent of both parents Enrolment in the social security system The other criteria per group are as follows: Group of adult subjects without ASD : Age between 18 and 50 years Group of children without ASD * Age between 2 and 12 years * Group of children with ASD Age between 2 and 12 years Conformity with the diagnostic criteria of ASD according to DSM-V, ICD-10 or ICD-11 Phase 2 * Group of children without TND : Age between 0 and 12 years * Group of children with TND, or whose diagnosis is in progress (via PCO referral) : Age between 0 and 12 years Conformity to the diagnostic criteria of TND
Exclusion criteria
Phase 1: All groups have the 2 common
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oculometric measurements 1: Tracking time | through study completion, an average of 1 year (first phase) and of 2 years (second phase) | Mean of tracking time (ms) during entire stimuli duration |
| Oculometric measurements 2: Fixation time on the screen | through study completion, an average of 1 year (first phase) and of 2 years (second phase) | Mean of fixation time on the screen (ms) during entire stimuli duration |
| Oculometric measurements 3: Fixation time on the eye area during entire stimuli duration | through study completion, an average of 1 year (first phase) and of 2 years (second phase) | Mean of fixation time on the eye area of face stimuli (ms) during entire stimuli duration |
| Oculometric measurements 4: Fixation time on the mouth area of face stimuli | through study completion, an average of 1 year (first phase) and of 2 years (second phase) | Mean of fixation time on the mouth area of face stimuli (ms) during entire stimuli duration |
| Pupillometric measurements | through study completion, an average of 1 year (first phase) and of 2 years (second phase) | Mean of pupil dilation variation(mm) in response to entire stimuli duration |
| Discriminative power | through study completion, an average of 1 year (first phase) and of 2 years (second phase) | AUROC (Area Under the Receiver Operating Characteristics, in percent) analysis of combined oculometric and pupillometric measurements. Scale score : 0-100% (above 70% : good performance; above 80% : excellent performance; above 90% : outstanding performance) |
Countries
France
Contacts
CONTACTNadia Aguillon-Hernandez, MCU
CONTACTYosra DRIDI
PRINCIPAL_INVESTIGATORNadia Aguillon-Hernandez, MCU
UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Outcome results
None listed