Parkinson, Parkinson Disease
Conditions
Keywords
Magnetic Resonance Imaging, MRI, Super Resolution
Brief summary
The goal of this study is to increase magnetic resonance image quality in patients suffering from Parkinson's disease. The main question it aims to answer is: can super-resolution improve clinical magnetic resonance image quality to benefit deep brain stimulation for Parkinson's disease? Participants will receive an additional high-quality MRI scan.
Detailed description
Rationale: Better targeting of the subthalamic nucleus (STN) improves the outcome of deep brain stimulation (DBS) for Parkinson's disease. Yet, the accuracy of delineating the STN, and therefore the targeting, is limited by the spatial resolution of the magnetic resonance (MR) imaging. The current study aims to acquire a high resolution (HR) MR dataset, tailored to visualise the STN, to train a super-resolution model to predict HR MR images based on lower resolution MR input. This model will aid delineating the STN and improve segmentation and targeting. Objective: To develop a deep learned super-resolution model that predicts high-resolution MR images with a peak signal-to-noise ratio of 37 decibel or higher. Study design: Prospective observational study. Study population: Twenty Parkinson's patients considered eligible for DBS surgery at Radboud University Medical Centre will be included. Main study parameters/endpoints: Peak signal-to-noise ratio measured in decibels.
Interventions
None listed
Sponsors
Radboud University Medical Center
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Patients eligible for bilateral STN-DBS-surgery for Parkinson's disease. * Signed informed consent
Exclusion criteria
* Any intracranial abnormality that is not in line with Parkinson's disease progression * Previous intracranial surgery * Any significant medical condition that is likely to interfere with study procedures. * Pregnancy at the time of enrollment. * Participation in any other clinical trial (e.g. drug, device, or biologics) that interferes with this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peak signal-to-noise ratio | Six months after study completion of the last subject. | The change in image quality as determined by the peak signal-to-noise ratio. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Structural similarity index measure | Six months after study completion of the last subject. | The change in image quality as determined by the structural similarity index measure. |
| Normalized root mean squared error | Six months after study completion of the last subject. | The change in image quality as determined by the normalized root mean squared error. |
Countries
Netherlands
Outcome results
None listed