Emotions, Stroke, Stroke Sequelae
Conditions
Keywords
stroke, emotions, neural bases
Brief summary
This monocentric physiological study will evaluate the neural bases of visual recognition of emotions in stroke patients vs. healthy controls using MRI (functional and structural connectivity) and EEG.
Detailed description
This monocentric physiological study will evaluate the neural bases of visual recognition of emotions in stroke patients vs healthy controls (2 groups of 40 subjects). It will include functional MRI, structural MRI (disconnectome), EEG, and behavioral assessments of emotion recognition and executive functions.
Interventions
None listed
Sponsors
University Hospital, Lille
Groupement Interrégional de Recherche Clinique et d'Innovation
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Stroke group: * Man or Woman * Age 18-80y * Unique stroke, ischemic or hemorrhagic * at the chronic phase (\< 6 months) * Written informed consent * subject having a social insurance * Subject who consent to complete all the study's experiments Healthy controls group: * Man or Woman * Age 18-80y * No history of neurological or psychiatric disease.
Exclusion criteria
Stroke group * Subject who is unable to consent (due to dementia, severe aphasia, psychiatric disorder...) * History of other neurologic disorders * Significant le vel of depression or anxiety, assessed by the STAI and the BDI questionnaires * Non corrected visual loss * Subjects suffering from visual neglect (assessed by the Bells Test and a bisection test (20mm) * contra-indications to MRI * pregnant or breastfeeding woman * Women of childbearing age without effective contraception Healthy controls group * Subject who is unable to consent (due to dementia, severe aphasia, psychiatric disorder...) * History of neurologic disorders * Significant level of depression or anxiety, assessed by the STAI and the BDI questionnaires * Non-corrected visual loss * contra-indications to MRI * pregnant or breastfeeding woman * Women of childbearing age without effective contraception
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| BOLD signal when fear visual recognition | 1 day | Compare correlations of cerebral functional activations (BOLD) by fMRI between groups when stimulus = fear |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| BOLD signal when happiness visual recognition | 1 day | Compare correlations of cerebral functional activations (BOLD) by fMRI between groups when stimulus = happiness |
| Electrical connectivity (EEG) when fear visual recognition | 1 day | Compare cerebral networks activated by a fear visual task recognition in both groups |
| Electrical connectivity (EEG) when fear happiness visual recognition | 1 day | Compare cerebral networks activated by a happiness visual task recognition in both groups |
| Electrical connectivity (EEG) when emotions auditory recognition | 1 day | Compare cerebral networks activated by an auditory task recognition in both groups |
| Relationship between behavioral performance and cerebral networks | 1 day | Correlations between fMRI and EEG networks vs. behavioral performance (emotion recognition) |
| Structural connectivity | 1 day | Disconnectome maps in the stroke patients group |
| Relationship between emotional self-assessment and cerebral networks | 1 day | Correlation between the ESQ (emotional state questionnaire) and cerebral connectivity (EEG) and fMRI networks |
| Relationship between the behavioural performance in emotion recognition and executive functions | 1 day | Correlation between behavioral performance in emotion recognition (Eckman Test) and executive functions (Stroop Test) in the stroke group |
| Relationship between lesion characteristics and the behavioral performance in emotion recognition | 1 day | Correlation between lesion volume and the behavioural performance in emotion recognition (Eckman Test) |
Countries
France
Contacts
PRINCIPAL_INVESTIGATOREtienne Allart, MD
University Hospital, Lille
Outcome results
None listed