Acute Liver Failure, Alcoholic Hepatitis
Conditions
Brief summary
Retrospective chart review will be conducted on patients at Methodist Dallas Medical Center, meeting the inclusion criteria from January 1, 2019 to December 15, 2020 to determine the transplant free survival and overall survival and other secondary outcome measures.
Detailed description
Retrospective chart review will be conducted on patients at Methodist Dallas Medical Center, meeting the inclusion criteria from January 1, 2019 to December 15, 2020 to determine the transplant free survival and overall survival and other secondary outcome measures. Patient's charts will be accessed on EPIC by the PI or delegated study personnel. The investigator's anticipate completion of this study by January 31, 2022.
Interventions
None listed
Sponsors
Methodist Health System
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
• The patient was diagnosed with: Alcoholic hepatitis; AoCLF; OR Acute fulminant liver failure • The patient underwent at least one round of dialysis using plasma exchange or MARSTM
Exclusion criteria
* Patient not meeting the inclusion criteria will be excluded. All patients who underwent MARS at MDMC will be included in the study population.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Transplant free survival mortality | Rate at 30 days | transplant will be measured by date of death, and discharge |
| Difference in Demographics | Rate at 30 days | co-morbidities, etiology of liver failure between those treated with MARS vs. controls |
| Improvement in Transplant | Rate at 30 days | Determine whether treatment with MARS can help facilitate improvement in HE, LOS, and ICU duration. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Demographics | January 1, 2019 to January 31, 2022 | age (years), gender (male/female), race (Caucasian, black, Hispanic, Asian, other), BMI (kg/m2) |
| Hepatorenal syndrome | (in hospital [date of death or discharge or transplant]) and at 30 days | Y/N |
| Need for vasopressor support | (in hospital [date of death or discharge or transplant]) and at 30 days | Y/N |
| Sepsis (as measured by by QSOFA criteria): | (in hospital [date of death or discharge or transplant]) and at 30 days | Y/N |
| Need for CRRT as documented in the chart: | (in hospital [date of death or discharge or transplant]) and at 30 days | Y/N |
| ICU duration | date of ICU admission and date of discharge (or death) | days of date of ICU duration |
| long term dialysis | (in hospital [date of death or discharge or transplant]) and at 30 days | Need for long term dialysis (Y/N) |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORParvez Mantry, MD
Methodist
Outcome results
None listed