Alopecia Areata
Conditions
Keywords
alopecia areata AA
Brief summary
Abstract: Alopecia areata is believed to be an autoimmune disease resulting from a breach in the immune privilege of the hair follicles causing non scarring hair loss. Methods: our study included 40 patients from may 2019 to july 2022 diagnosed clinically, dermatoscopically and pathologically as alopecia areata Data were enrolled from department of dermatology and venereology, Al-Hussein hospital.
Detailed description
For each patient the following will be done : 1. History taking including ( age, sex, disease duration, family history, history of drug intake, smoking and history of any associated disease ). 2. All patients will give a written, informed consent for induction. 3. Basic photographs will be taken to assess site, size (by cm), number, Extent of the patch using D5300 camera with lens (18-55). 4. Patients will be subjected to 3 session of trichloroacetic acid (TCA) 35% one month apart. 5. serial photographs and dermoscopic examination every month will be done and patient will be score. 6. Efficacy will be assessed using prognostic scoring system for density, pigmentation, and texture of growing hair. 7. histopathological examination will be done before the first session and one month after third session.
Interventions
5\. Patients will be subjected to 3 session of trichloroacetic acid 35% one month apart.
Sponsors
Al-Azhar University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
16 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Alopecia areata multilocularis and alopecia totalis. Age from 16-60 years old. Ophiasis pattern alopecia areata.
Exclusion criteria
* Age less than 16 and more than 60years old. Alopecia areata of the face. * Patient under treatment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mac Donald Hull and Norris grading system | 4 weeks after the end of treatment | regrowth of vellus hair, regrowth of sparse pigmented terminal hair, regrowth of terminal hair with patches of alopecia and regrowth of terminal hair on scalp. |
| Scoring of texture of regrown hair | after each session and 4 weeks after the end of treatment | Fine vellus hair, Intermediate hair,Normal coarse hair |
| Scoring of pigmentation of regrown hair | after each session and 4 weeks after the end of treatment | Partially pigmented, Moderately pigmented, Normally pigmented |
| Scoring for density of hair regrowth | after each session and 4 weeks after the end of treatment | No hair growth, 1%-25% growth, 26%-50% growth, 51%-75% growth and 76%-100% growth |
| Scoring of overall response at the end of the study | after each session and 4 weeks after the end of treatment | No response, Minimal response, Moderate response, Good response and Excellent response |
| histopathological changes | after each session and 4 weeks after the end of treatment | appearance of lymphocytes around hair follicle, appearance of new blood vessels and size of thickness of hair follicles |
| trichoscopic parameters | after each session and 4 weeks after the end of treatment | determine exclamation mark hairs, black dots, yellow dots and broken hairs |
Countries
Egypt
Outcome results
None listed