Spondylarthritis
Conditions
Brief summary
There are, to date, no validated biomarkers or head-to-head RCTs of biologics to guide choice of biologic agent in axSpA. While there are now two head-to-head studies of a TNF inhibitor (TNFi) vs an IL-17 inhibitor (IL-17i) in psoriatic arthritis. Recommendations refers to biological DMARDs (bDMARDs) including TNFi and IL-17i for patients with high disease activity despite the use (or intolerance/contraindication) of at least two non-steroidal anti-inflammatory drugs (NSAIDs) in axial SpA (axSpA) and in failure of a strategy including methotrexate for psoriatic arthritis. A tool to help us to decide which bDMARDs to use is necessary. In SpA, the method of determination of IL17 seems to be questionable. The determination of cytokines after stimulation of immune cells in patients with active SpA requiring a biological treatment could provide us with a tool to assist in the choice of therapy. The aim of the study was to show the feasibility of cytokine assay following lymphocyte stimulation in active SpA requiring biological treatment. And secondly, to show the predictive character of this expression on the therapeutic response at three months after the implementation of a biological treatment.
Interventions
OTHERBlood sample
Blood samples required to performe IL-17 Dosage
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Inclusion criteria
* Patients with spondyloarthritis meeting the ASAS criteria * Patients who were to benefit from the implementation of a biological treatment after failure of at least two NSAIDs. * Patients having an active disease defined by a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) higher than four,
Exclusion criteria
* No predominant axial manifestation, * Having received a previous biological treatment * Patients presenting contraindication to the implementation of these treatments.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| to show the feasibility of cytokine assay following lymphocyte stimulation in active SpA requiring biological treatment. | 18 months | rate of IL17 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| predictive value of IL17 rate | 18 months | to show the predictive character of this expression on the therapeutic response at three months after the implementation of a biological treatment. Response will be evaluated by BASDAI50 |
Countries
France
Contacts
Primary ContactChristian ROUX
Backup ContactBarbara SEITZ-POLSKI
Outcome results
None listed