Chronic Obstructive Pulmonary Disease
Conditions
Brief summary
COPD causes an acute deterioration of respiratory symptoms, particularly increased breathlessness and cough, and increased sputum volume and/or purulence. Worsening airflow limitation is associated with an increasing prevalence of exacerbations and risk of death. These exacerbations can range from self-limited diseases to episodes of florid respiratory failure requiring mechanical ventilation .Hospitalization for COPD patients post COVID is associated with poor prognosis with increased risk of death. Hence techniques of efficient clearance of peripheral airways may reduce airway occlusion by excess mucus and inflammatory cells, improving lung function, exercise capacity and reducing exacerbation frequency.
Detailed description
Patients were assigned to 2 groups with pre- and post- treatment protocol application. All patients were thoroughly evaluated before and after treatment protocol application. Thirty patients (Group A) received high frequency chest wall oscillation with vest system in addition to their prescribed medication, 3 times per week for three successive weeks and the total duration of each session was 15-30 minutes. Thirty patients (Group B) received Lung flute (OPEP) in addition to their prescribed medication, 2 times per week twice a day for three successive weeks and the total duration of each session was 10-15 minutes
Interventions
DEVICEhigh frequency chest wall oscillation with vest system
Patients were assigned to 2 groups with pre- and post- treatment protocol application. All patients were thoroughly evaluated before and after treatment protocol application.
DEVICELung flute (OPEP)
. Thirty patients (Group B) received Lung flute (OPEP) in addition to their prescribed medication, 3 times per week twice a day for three successive weeks
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
40 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* All patients aged 40-60 years old * All patients were recovered from COVID not more than 3 months * All patients were diagnosed as COPD for at least two years ago. * All patients had irreversible/ partially reversible obstruction of airflow. * COPD patients had a post-bronchodilator, FEV1/FVC% \< 70%. They had an increase in FEV1\< 200 ml, or \< 12% of baseline value 20 minutes after 2 puffs of inhaled salbutamol (100 µg) given via a metered-dose inhaler.
Exclusion criteria
* Presence of malignant disease. * Patients with acute infection. * History of osteoporosis, significant gastro-oesophageal reflux, hiatus hernia. * Recent acute cardiac event (6 weeks) or congestive cardiac failure. * Any significant musculoskeletal disorders.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Forced vital capacity (FVC) | Forced vital capacity (FVC)will be measured at baseline, and after three weeks. | FVC is the amount of air that can be forcibly exhaled from lungs after deepest inspiration, it's measured by spirometry |
| Forced expiratory volume in one second (FEV1) | FEV1 will be measured at baseline, and after three weeks. | FEV1 is the maximum amount of air that the subject can forcibly expel during the first second following maximal inhalation |
| FEV1/FVC ratio | FEV1/FVC ratio will be measured at baseline, and after three weeks. | The FEV1/FVC is a ratio that reflects the amount of air you can forcefully exhale from your lungs. It's measured by spirometry, a test used to evaluate lung function |
| The forced mid-expiratory flow (FEF25-75%) | (FEF25-75%) will be measured at baseline, and after three weeks. | (FEF25-75) measures the average flow rates of medium-to-small airways during the forced vital capacity (FVC).it' is a potentially sensitive marker of obstructive peripheral airflow |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Six-minute walk test | 6min walk test will be measured at baseline, and after three weeks. | Six-minute walk test was carried out before and after interventions to determine the patient functional capacity |
| COPD assessment test (CAT | COPD assessment test (CAT)will be measured at baseline, and after three weeks. | is a validated, short (8-item) and simple patient completed questionnaire |
Countries
Egypt
Contacts
Primary ContactAlaa El-Moatasem, lecturer
Backup ContactOmnia Ahmed, Lecturer
Outcome results
None listed