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Dexmedetomidine vs Dexamethasone as Adjuvant to Bupivacaine in Bilevel Erector Spinae Plane Block in Breast Surgeries

Comparison of Dexmedetomidine and Dexamethasone as Adjuvant to Bupivacaine in Ultrasound-guided Bilevel Erector Spinae Plane Block in Modified Radical Mastectomy

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05591417
Enrollment
68
Registered
2022-10-24
Start date
2022-10-27
Completion date
2024-09-30
Last updated
2024-10-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesia

Brief summary

High percent of patients experience chronic pain following breast cancer surgeries thus proper perioperative pain control is crucial to lessen the incidence of such pain. Several techniques are adopted to control perioperative pain, these techniques include drugs as opioids and adjuvants as well as regional blocks. Erector spinae plane block is a regional technique that is used efficiently to control perioperative pain during and following breast cancer surgeries.

Detailed description

High percent of patients experience chronic pain following breast cancer surgeries thus proper perioperative pain control is crucial to lessen the incidence of such pain. Several techniques are adopted to control perioperative pain, these techniques include drugs as opioids and adjuvants as well as regional blocks. Erector spinae plane block is a regional technique that is used efficiently to control perioperative pain during and following breast cancer surgeries. Adding adjuvant drugs as dexmedetomidine or dexamethasone can augment the local anesthetic effect for the regional block used.

Interventions

PROCEDUREBilevel Erector spinae plane block

Patients will receive bilevel erector spinae plane block with bupivacaine

PROCEDUREBilateral Erector spinae plane block with dexamethasone

Patients will receive bilevel erector spinae plane block with bupivacaine and dexamethasone

PROCEDUREBilateral Erector spinae plane block with dexmedetomidine

Patients will receive bilevel erector spinae plane block with bupivacaine and dexmedetomidine

DRUGIntravenous morphine

Intravenous morphine 0.1 mg/kg

Sponsors

National Cancer Institute, Egypt
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Female patients scheduled for Modified Radical Mastectomy MRM * Physical status ASA II, III. * Age (18-65) years * Body mass index (BMI): (20-35) kg/m2.

Exclusion criteria

* Patient refusal. * Age \<18 years or \>65 years. * BMI \<20 kg/m2 and \>35 kg/m2. * Known sensitivity or contraindication to drug used in the study (local anaesthetics, opioids, dexamethasone, dexmedetomedine).

Design outcomes

Primary

MeasureTime frameDescription
Total morphine consumption in the first 24 hours postoperatively.First 24 hours postoperativelyAssessment of total postoperative morphine consumption

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026