Inflammation Vascular
Conditions
Keywords
diabetes mellitus, acute coronary syndrome, coronary inflammation, coronary computed tomography angiography, fat attenuation index
Brief summary
This study aimed to clarify the relationship between blood glucose control and the FAI based pericoronary inflammation in low-risk ACS patients with or without diabetes. The results of this study are expected to provide evidence that quantitative assessment of pericoronary FAI helps monitor the local inflammatory activation in diabetic patients with poor glycemic control, therefore, pericoronary FAI evaluation, as a noninvasive imaging biomarker, plays an important role in early detecting coronary atherosclerosis risk in diabetes and allow timely providing appropriate risk reduction strategies in patients at high risk for future cardiovascular events.
Detailed description
Coronary inflammation has been shown to be a cause of the significantly increased risk of cardiovascular disease (CVD) in diabetic patients. This study aimed to investigate the relationship between coronary local inflammation detected by pericoronary fat attenuation index (FAI) and different blood glucose control levels in low-risk acute coronary syndrome (ACS) patients with or without diabetes.A total of 309 patients with low-risk ACS were included in the analysis. Patients were classified into three groups: non-diabetes, well-regulated diabetes and poorly regulated diabetes, depend on the presence or absence of diabetes and the glycemic control evaluated based on a target HbA1c value of 7%. Pericoronary FAI around the proximal of left anterior descending artery (LAD), left circumflex artery (LCX), and right coronary artery (RCA) were evaluated by CCTA, while systemic inflammatory variables and other biochemical indicators were detected by flow cytometry. The results of this study are expected to provide evidence that quantitative assessment of pericoronary FAI helps monitor the local inflammatory activation in diabetic patients with poor glycemic control, therefore, pericoronary FAI evaluation, as a noninvasive imaging biomarker, plays an important role in early detecting coronary atherosclerosis risk in diabetes and allow timely providing appropriate risk reduction strategies in patients at high risk for future cardiovascular events.
Interventions
None listed
Sponsors
RenJi Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* patients exhibited chest pain but troponin negative who suspected of low-risk ACS\[17\]; * patients underwent CCTA examination before elective coronary angiography; * patients with at least one significant stenosis (≥50%) in major epicardial vessels based on coronary angiography.
Exclusion criteria
* patients with missing preprocedural HbA1c values; * patients with insufficient image quality for FAI analysis, * patients with previous history of coronary revascularization or myocardial infarction, or chronic kidney disease requiring hemodialysis, or malignant tumor, or immune system disorders, or statin use within 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pericoronary Fat attenuation index (FAI) | 2021.1.1-2022.10.31 | The pericoronary FAI was defined as the mean CT attenuation of the pericoronary adipose tissue (-190 to -30 HU). Peri-stent FAI was measured around the stent segment of all 3 major epicardial coronary vessels. |
Secondary
| Measure | Time frame |
|---|---|
| level of pro-inflammatory cytokines such as IL-2 and IL-6. | 2021.1.1-2022.10.31 |
| Level of hsCRP | 2021.1.1-2022.10.31 |
Countries
China
Outcome results
None listed