Type 2 Diabetes Mellitus, Mild Cognitive Impairment
Conditions
Keywords
Cognitive Assessments, Olfactory Test, Risk Model
Brief summary
Development and validation of a risk model for predicting the risk of mild cognitive impairment among individuals of type 2 diabetes.
Interventions
OTHERTests
Cognitive assessments and olfactory tests
Sponsors
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients with type 2 diabetes mellitus ; * Aged:40 -80 years ; * Montreal Cognitive Assessment Scale (MoCA) scores 19 - 30;
Exclusion criteria
* Mini-mental State Examination(MMSE) scores \< 24; * Other dementia related neurological diseases or depression, schizophrenia in the past 2 years; * Central nervous system diseases, including brain trauma, intracranial hemorrhage, acute cerebral infarction; * Severe sinusitis, nasal cavity and sinus polyps, skull base or nasopharyngeal tumors and other space occupying lesions, congenital diseases and traumatic history of nose, maxillofacial and skull base affecting olfaction; * Diabetic acute and chronic complications, including diabetic ketoacidosis, a hyperglycemic hyperosmolar state or severe hypoglycemic coma.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The rate of mild cognitive impairment occurrence | 1 year | The rate of Montreal Cognitive Assessment(MoCA) scores less than 26 points after 1 year's follow-up. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Glycaemic control measured by blood test. | 1 day | HbA1c |
| Physical assessments. | 1 day | BMI(body mess index) in kg/m\^2 |
| Olfactory threshold test | 1 day | The same odor with 2 different concentrations are given to the participant each time to find out which one is more intense. (Olfactory software will analyse and give threshold score depending on participant's choice.) |
| Olfactory memory test | 1 day | PART A: Participants are shown 4 pictures for each odor(10 odors in total). They select what they sniffed. 10 minutes break. PART B: Participants sniff 20 different odors , 10 of which are same odors in PART A. They select the picture and figure out whether the odor is old or new. |
| Montreal Cognitive Assessment (MoCA) score | 1 day | The MoCA is a cognitive screening test designed to assist health professionals in detection of mild cognitive impairment. |
Countries
China
Contacts
Primary ContactBi Yan, MD, PhD
Outcome results
None listed