Asthma, Cardiovascular Diseases
Conditions
Keywords
Asthma, Cardiovascular Diseases, Chronic inflammation, Bronchial remodeling, Eosinophilia
Brief summary
To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease.
Detailed description
Recent studies have shown that asthma could be a risk factor for cardiovascular disease, especially in the female and late-onset subgroups. The two entities share several risk factors, such as chronic inflammation and bronchial remodeling. Eosinophilia, characteristic of asthma, has also been described as a predictor of cardiovascular mortality. The aim of this study is to determine the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease, as well as their relationship with eosinophil subtypes, biomarkers of chronic inflammation and bronchial remodeling.
Interventions
OTHERAsthma and cardiovascular disease
To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease, as well as their relationship with eosinophil subtypes, biomarkers of chronic inflammation and bronchial remodeling.
Sponsors
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Previous diagnosis of asthma * Signed informed consent
Exclusion criteria
* Age under 18 years old * Age over 99 years old * Pneumological diseases other than asthma * Active oncological diseases or with end of treatment \<5 years * Autoimmune or systemic inflammatory diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical characteristics of patients with asthma | 1 year | Spirometry with bronchodilator testing |
| Associated cardiovascular disease type | 1 year | Cardiac infarction, stroke or peripheral artery disease |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Eosinophil subtypes | 1 year | Eosinophil subtypes of patients with asthma and cardiovascular disease |
| Biomarkers of chronic inflammation | 1 year | Transforming growth factor-β, interleukin-5, interleukin-13, interleukin-25 and interleukin-3 |
| Bronchial remodeling | 1 year | Bronchial remodeling of patients with asthma and cardiovascular disease measured by analysis of images obtained by thoracic CT scanning |
Contacts
Primary ContactEsther Palones, MD
Outcome results
None listed