Spinal Metastases
Conditions
Brief summary
This is a single institutional registry-based, prospective, observational study to describe radiation oncologists' decision making during evaluation of patients and to compare real-world outcomes of SBRT vs CRT. A registry-based trial involves observing the effect of something without manipulating it.
Detailed description
The purpose of this study is to study the differences between CRT and SBRT. The investigator's are assessing radiation oncologists' decision-making during the evaluation of patients with spinal metastases by requesting radiation oncologists complete a questionnaire. Additionally, the investigator's will compare outcomes, including local progression, pain response and overall survival between SBRT and CRT. By collecting this information, the investigator's will develop an evidence-based algorithm that may be used to support medical decision-making for others with spinal metastases in the future.
Interventions
RADIATIONRadiotherapy
Standard of care radiotherapy administered as per institutional guidelines.
Sponsors
University Health Network, Toronto
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Adults 18 years of age or older. * Patients seen at the Princess Margaret Cancer Centre with painful spinal metastases amenable to radiation treatment. * Confirmation of diagnosis: a) Known/documented prior histological cancer diagnosis * Able to provide written consent * ECOG performance status 0-3
Exclusion criteria
* Prior radiotherapy, with fields overlapping, resulting in excessive doses to organs at risk * Lymphoma, myeloma or germ cell malignancies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Describe physician decision-making when making a recommendation for SBRT vs CRT in spine metastasis patients requiring radiation. | 2 years | Physician's decision making will be assessed by a questionnaire containing 6 questions, including questions on variations of practice and the role of a number of factors that may influence a physician's recommendation for spine metastasis patients requiring radiation (SBRT vs CRT). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assess local progression free survival. | 2 years | Based on available imaging, compare local progression free survival outcomes of patients treated with SBRT vs CRT. |
| Measure pain response | 2 years | Using a patient reported scale (0 (no pain) to 10 (worst pain imaginable)), compare pain outcomes of patients treated with SBRT vs CRT. |
| Assess adverse events | 2 years | Compare adverse events, collected through standard of care follow up, which occur for patients treated with SBRT vs CRT. |
| Measure overall survival | 2 years | Compare overall survival, collected through medical records, for patients treated with SBRT vs CRT. |
Countries
Canada
Contacts
CONTACTDavid Shultz, MD
Outcome results
None listed