Simple Steatosis Non Fatty Liver
Conditions
Brief summary
Effect of N-acetyl cysteine on markers of oxidative stress and insulin resistance in patients with Non-alcoholic fatty liver disease
Interventions
DRUGN acetyl cysteine with weight reduction
high dose 2400mg/day
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Males or females aged 18-60 years diagnosed with NAFLD
Exclusion criteria
* History of alcohol consumption, drug addiction or the use of medications known to precipitate steatohepatitis. * Patients with schistosomiasis, active hepatitis B or C, autoimmune and diabetes mellitus. * current Consumption of any antioxidant supplements and hepatotoxic drug. * Pregnancy or lactation or expecting to get pregnant during the study. * Medical, psychological, or pharmacological factors interfering with the collection or interpretation of study data. * Active Cancer patients. * Anyone having hypersensitivity to N-acetylcysteine. * Anyone already taking N-acetylcysteine.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| assessment of the effect of NAC on leptin | 3 months | leptin as insulin resistance marker in NAFLD |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| assessment of the effect of NAC on MDA | 3 months | MDA as oxidative stress marker in NAFLD |
Countries
Egypt
Outcome results
None listed