Postoperative Pain
Conditions
Keywords
postoperative analgesia, pain score, side effect, morphine, intrathecal
Brief summary
Thoracic surgery is one of the surgeries where postoperative pain is intense. In this study, the investigators aimed to compare the efficacy of two different intrathecal morphine doses administered for postoperative analgesia according to patients' ideal body weight.
Detailed description
Patients who underwent video-assisted thoracic surgery were divided into two groups: 10 mcg/kg and 7 mcg/kg intrathecal morphine for postoperative analgesia. Intraoperative and postoperative hemodynamic variables, postoperative morphine consumption, postoperative pain scores, side effects and additional analgesic requiretment were recorded.
Interventions
DRUGMorphine
In the literature, intrathecal morphine doses were applied according to the patients' actual body weight and there is no study comparing intrathecal morphine dose in thoracic surgery patients.
Sponsors
Cukurova University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* \> 18 years old * ASA class I and II * Video-assisted thoracoscopic surgery
Exclusion criteria
* \< 18 years old * ASA class \> II * Serious hepatic, cardiac, renal, metabolic, endocrine diseases * Coagulation disfunction * Allergy to any of the study drugs * Pneumonectomy * Infection in the lumbar region
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pain scores | Change from baseline pain scores at 24 hours | Postoperative pain scores of the patients were recorded via Visual Analog Scale (VAS; 0= no pain, 10= worst pain) |
| morphine consumption | Change from baseline morphine consumption at 24 hours | At the end of surgery, patients were allowed to use the patient controlled analgesia (PCA) device. The PCA delivered bolus doses of morphine (0.02 mg/kg) every 10 minutes without a backround infusion. Morphine consumption (mg) was evaluated and recorded postoperative 24 hours. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| diastolic arterial blood pressure | change from baseline diastolic blood pressure at 150 minutes | Intraoperative diastolic arterial blood pressure (mmHg) values were recorded during surgery. |
| heart rate | change from baseline heart rate at 150 minutes | Intraoperative heart rate (beats/minute) values were recorded during surgery. |
| side effects | postoperative 24 hours | All of patients were visited in the thoracic surgery ward after surgery and side effects were evaluated and recorded. |
| mean arterial blood pressure | change from baseline mean arterial blood pressure at 150 minutes | Intraoperative mean arterial blood pressure (mmHg) values were recorded during surgery. |
| systolic arterial blood pressure | change from baseline systolic blood pressure at 150 minutes | Intraoperative systolic arterial blood pressure (mmHg) values were recorded during surgery. |
Countries
Turkey (Türkiye)
Outcome results
None listed