Comorbidities and Coexisting Conditions, Hypercalcemia, Hypocalcemia, Morality, Quality of Life
Conditions
Brief summary
Long-term conventional treatment of chronic hypoparathyroidism does not fully restore calcium homeostasis leading to increased morbidity, emergency events and reduced subjective health status. To further investigate general morbidity, hypocalcemic events, subjective and daily life performance in patients with chronic hypoparathyroidism a standardized interview as well as blood sampling and examinations such as echocardiography and renal ultrasound are performed.
Detailed description
Design: In a longitudinal prospective trial the comorbidities, mortality, hypocalcemic and hypercalcemic events and quality of life in patients with chronic hypoparathyroidism will be evaluated by a standardized interview, blood sampling and further examinations such as echocardiography and renal ultrasound. Patients: Patients will be recruited out of the patient population of the University Hospital Wuerzburg. Statistical Analysis: Documentation and analysis will be performed at the Department of Medicine I, Endocrine and Diabetes Unit, University of Würzburg, Germany. Data will be documented after pseudonymisation in a data base. For further analysis data will be compared to sex- and age-matched controls.
Interventions
None listed
Sponsors
University of Wuerzburg
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age of 18 * chronic hypoparathyroidism (\>12 months) under established therapy or chronic pseudohypoparathyroidism (\>12 months) under established therapy * written informed consent
Exclusion criteria
* age \<18 years * no detailed documentation of hypo- or pseudohypoparathyroidism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comorbidites | 15 years | Comorbidities such as renal diseases, cardiovascular disease, psychiatric diseases under treatment |
| Subjective health status | 15 years | Assessment of the subjective health status by standardized quality of life (QoL) questionnaires (e.g. short form-36, Patient Health Questionnaire 28) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hypocalcemic and hypercalcemic events | 15 years | documentation of frequency of hypocalcemia under standard treatment |
| Mortality | 15 years | — |
Countries
Germany
Contacts
Primary ContactStefanie Hahner, MD
Outcome results
None listed