The Changes in End Expiratory Lung Impedence Measured by EIT and End Expiratory Lung Volume Measured by Passive Expiratory in Controlled Mechanical Ventilated Exacerbation COPD Patients

The Relevance and Consistency Study of Changes in End Expiratory Lung Impedence Measured by EIT and End Expiratory Lung Volume Measured by Passive Expiratory in Controlled Mechanical Ventilated Exacerbation COPD Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05585060

Enrollment

Registered

2022-10-18

Start date

2022-09-13

Completion date

2023-10-08

Last updated

2022-11-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD

Keywords

COPD, dynamic pulmonary hyperinflation, mechanical ventilation, end expiratory lung impedence

Brief summary

The pathophysiological characteristics of respiratory failure on exacerbation of chronic pulmonary obstructive disease are the rapid deteriorate of respiratory symptoms, combined with aggravated flow limitation, gas trapping, dynamic pulmonary hyperinflation (DPH), therefore the intrinsic PEEP (PEEPi) increases. It is worthwhile to explore bedside methods to quantify the changes in dynamic pulmonary hyperinflation to guide safe and effective mechanical ventilation in airflow limited patients.

Detailed description

The study hypothesizes that the electrical impedence tomography (EIT) measured the changes of end expiratory lung impedence (△EELI） could accurately predict the changes of end expiratory lung volume （△EELV） measured by passive expiratory in controlled mechanical ventilated exacerbation COPD patients. The research intended to conduct a research to explore the relationship between △EELI and △EELV induced by external PEEP changes in ventilated exacerbation COPD patients.

Interventions

DIAGNOSTIC_TESTthe changes of end expiratory lung impedence

the changes of end expiratory lung impedence measured by EIT

DIAGNOSTIC_TESTthe changes of end expiratory lung volume

the changes of end expiratory lung volume measured by apnea method

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

35 Years to 80 Years

Healthy volunteers

Inclusion criteria

* 2022.7-2023.1 exacerbation COPD invasive ventilated patients admitted to the first affiliated Guangzhou medical university; 35 to 80 years old; in stable condition judged by clinicians

Exclusion criteria

* SpO2\<88%; instable hemodynamic (MAP\<65mmHg；Norepinephrine\> 0.1ug/kg.min); pregnancy; 4 hour intravenous diuretics use before research; chest deformity and trauma, subpleural pulmonary bulla; implanted electronic devices(cardiac pacemaker, implantable cardioversion defibrillator,ect); tumour or other organ dysfunction; refuse to signature the informed consent

Design outcomes

Primary

Measure	Time frame	Description
the changes of end expiratory lung volume	10 minutes	measured by EIT and IC maneuver

Secondary

Measure	Time frame	Description
intrinsic PEEP	10 minutes	measured by Esophageal balloon catheters

Countries

China

Contacts

Primary ContactWei Fu, MD

hooray_009@163.com+8602083062882

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026