White Spot Lesion
Conditions
Brief summary
The modern concept in caries treatment focuses on the non-invasive approach and on the biomimetic remineralization of early non-cavitated white spot carious lesions. Recently developed biomimetic scaffolds attempt to remineralize the dental tissues and are more regenerative than reparative.
Interventions
OTHERCurodont repair Self- assembling peptide P11-4
The labial surface of each tooth in both arches from central to the first premolar on both sides will be treated by Curodont
OTHERPh-chi phosphorylated - nano-chitosan
The labial surface of each tooth in both arches from central to the first premolar on both sides will be treated by Ph-chi phosphorylated - nano-chitosan
OTHERCCP-ACP +ve control Casein phosphopeptide amorphous calcium phosphate
The labial surface of each tooth in both arches from central to the first premolar on both sides will be treated by CCP-ACP
Sponsors
Hams Hamed Abdelrahman
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Patients who at least have 1 white spot lesion. * No systemic diseases or taking any medication affecting salivary flow. * Patients with good oral hygiene measures. * Patients with moderate caries risk assessment. * Post orthodontic WSLs with International Caries Detection and Assessment System (ICDAS II) scoring criteria (1-2).
Exclusion criteria
* Participant in another trial. * Developmental non carious lesion (enamel hypoplasia and dental fluorosis). * Presence of abnormal oral disease, or medically compromised patients. * Participants who had evidence of reduced salivary flow or significant tooth wear. * Allergy to milk products or other drug allergies.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in DIAGNOdent values | Baseline, 1 month, 3 months , 6 months, 9 months, 12 months | The DIAGNOdent uses laser fluorescence to aid in the detection of caries within the tooth structure. |
| change in ICDAS scores | Baseline, 1 month, 3 months , 6 months, 9 months, 12 months | Code Description 0: Sound tooth surface: No evidence of caries after 5 sec air drying 1. First visual change in enamel: Opacity or discoloration (white or brown) is visible at the entrance to the pit or fissure seen after prolonged air drying 2. Distinct visual change in enamel visible when wet, lesion must be visible when dry 3. Localized enamel breakdown (without clinical visual signs of dentinal involvement) seen when wet and after prolonged drying 4. Underlying dark shadow from dentine 5. Distinct cavity with visible dentine 6. Extensive (more than half the surface) distinct cavity with visible dentine |
Countries
Egypt
Contacts
Primary ContactEman M Elsayed, Msc
Outcome results
None listed