Postprandial Plasma Amino Acid Availability
Conditions
Brief summary
The bulk of research that has investigated the effect of dietary protein on muscle tissue in humans has used isolated, minimally processed protein powders. However, the protein that we consume on a daily basis has typically undergone various processing methods, and evidence suggests these can change the way our bodies metabolise the protein. 'Extrusion' is a common processing method that uses high pressure to produce protein containing cereals and meat replacement foods. There is currently no research looking at how extrusion affects the way a protein source is digested and absorbed in humans. This study will compare the availability of ingested protein in the blood in the hours following consumption of an extruded versus a non-extruded source.
Interventions
DIETARY_SUPPLEMENTDry protein blend ingestion
Ingestion of protein blend powders mixed in water
DIETARY_SUPPLEMENTExtruded protein blend ingestion
Ingestion of protein blend powders mixed in water
Sponsors
Quorn
University of Exeter
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI between 18 and 30. * Metabolically healthy
Exclusion criteria
* Any metabolic impairments * cardio/pulmonary diseases. * Chronic use of the over the counter medicine * A personal or family history of epilepsy, seizures or schizophrenia. * Allergic to mycoprotein/Quorn/edible fungi/environmental mould products.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasma amino acid concentrations | 5 hours | The rate of appearance of amino acids ingested in the drink |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood glucose | 5 hours | The concentrations of glucose in the blood |
| Serum insulin | 5 hours | The concentration of insulin in the blood |
| Resting metabolic rate | 5 hours | The amount of energy used to digest the protein |
Countries
United Kingdom
Outcome results
None listed