Cellulitis of Leg
Conditions
Keywords
Primary care, Antibiotic treatment, Antibiotic resistance, Pain, Cost consequences
Brief summary
To determine whether a short course of oral flucloxacillin (5 days) is non-inferior to a standard course (7 days) in terms of pain over days 6-14 (indicative of persistence or recurrence associated with the symptoms of most importance to patients) in adults with cellulitis of the leg presenting in primary care.
Detailed description
Cellulitis is a deep infection of the skin and subcutaneous tissues and most often occurs in the legs. It is a painful condition that is associated with inflammation and swelling of the site, and often systemic symptoms such as fever, headache, muscle aches, malaise, and fatigue. Patients report feeling unwell and that it has a significant impact on their mobility and ability to carry out their usual activities. NICE guidelines recommend oral flucloxacillin 500-1000 mg four times daily for 5-7 days as first-line treatment for most patients with cellulitis in the community, but most prescriptions are dispensed for a 7-day course. We will be assessing the effectiveness and safety of a 5-day treatment vs. the standard 7-day treatment. We also aim to evaluate the cost-consequences of a shorter course from an NHS and personal perspective. Participants will be randomly allocated to one of two groups. In addition to usual care, participants will either be assigned to a 5-day oral flucloxacillin course or a standard 7-day flucloxacillin course. Participants will be prescribed a 5-day course of oral flucloxacillin, and two additional tablets will be posted to the participants which will either be the antibiotic or a placebo tablet. Participants will be asked to fill out daily questionnaires and express their experiences with the shortened course and taking part in the trial.
Interventions
DRUGFlucloxacillin Only Product in Oral Dose Form
Patients will be prescribed flucloxacillin 500mg QDS for 5 days followed by blinded flucloxacillin 500mg for 2 days, reaching a total of 7 days of antibiotic treatment
DRUGPlacebo Only Product in Oral Dose Form
Patients will be prescribed flucloxacillin 500mg QDS for 5 days followed by a blinded placebo for 2 days, reaching a total of 5 days of antibiotic treatment
Sponsors
University of Southampton
University of East Anglia
University of Nottingham
Norfolk and Norwich University Hospitals NHS Foundation Trust
University Hospital Southampton NHS Foundation Trust
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Masking description
To facilitate ease of recruitment and avoid treatment delay, participants will be provided with an NHS prescription for flucloxacillin 500mg QDS for the first 5 days. A blinded medication pack will be sent by next day delivery, containing flucloxacillin 500mg QDS, or matched placebo QDS for the final 2 days. Participants will be informed that the capsules in this pack may look different from the capsules they were taking on days 1-5. Participants experiencing significant clinical deterioration, as judged by their clinician, may have their antibiotic treatment changed or be prescribed additional antibiotic courses. Any changes or additional use of antibiotics will be recorded, and the patient and clinician will remain blinded unless unblinding is deemed necessary.
Intervention model description
A phase III blinded, multi-center, non-inferiority trial assessing the effectiveness and safety of 5 days vs 7 days of oral flucloxacillin 500mg QDS for lower leg cellulitis, and to evaluate the cost-consequences of a shorter course from an NHS and personal perspective. Participants will be recruited in NHS primary care settings in England and Wales. We will primarily recruit through general practices but will explore the possibility of recruiting through out-of-the-hours and urgent care settings.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Must be aged 18 years or older * Currently showing symptoms of cellulitis (such as pain, tenderness, redness, other change in skin color, warmth to touch) in one leg for 10 days or less * Pain rated as 3/10 or higher on a numerical rating scale (0-10) at baseline assessment * Be willing to be randomized to either trial arm (5-day or 7-day treatment) * Able to complete trial procedures in the English language.
Exclusion criteria
* Have penicillin allergy * Have bilateral cellulitis * Have had antibiotics for cellulitis within the past month * Have post-operative cellulitis (within 30 days of operative procedures on the same leg) * Have cellulitis resulting from human/animal bite injury * Have Cellulitis associated with chronic (\>6 weeks) leg ulceration * Require immediate hospital admission or out-patient intravenous antibiotic therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain assessment | Days 7-16 | Self-reported pain (measured using the Pain Numeric Rating Scale (0-10)) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Complications over 12 months | 12 months | Number of reported complications since randomisation, collected from primary care notes review |
| Time until self-reported recovery | Day 7, 14, 21, 28 | Participant reported questionnaire |
| Time until self-assessed extent of cellulitis starts to reduce (with no subsequent increase) | Day 7, 14, 21, 28 | Participant reported questionnaire |
| Hospital admissions | 12 months | Number of hosptial admissions since randomisation, collected from primary care notes review |
| Use of additional antibiotics | Up to day 28 | Any reported use of antibiotics other than the initial 5 days of flucloxacillin and 2 days of IMP) |
| Patient-reported assessment of how well they are feeling | Days 6-14 | Numeric rating scale NRS (0-10) and assessed as repeated measures |
| Health related quality of life | Days 6-14 | EQ-5D-5L - values, and individual dimension (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) level scores using repeated measures. |
| Health related quality of life used to estimate Quality Adjusted- Life Years (QALYs) | Days 6-14 | EQ-5D-5L - values, and individual dimension (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) level scores using repeated measures. |
| Recurrent cellulitis episodes over 12 months (number of episodes) | 12 months | Recurrent cellulitis episodes over 12 months (number of episodes) since randomisation, collected from primary care notes review |
| Leg swelling and warmth | Day 7, 14, 21, 28 | Participant reported questionnaire |
Countries
United Kingdom
Contacts
CONTACTSophie Varkonyi-Clifford
CONTACTElla Bourke
Outcome results
None listed