Clinical & Biochemical Effect of Atorvastatin in Nano Particles Gel in Periodontitis Treatment

Syringeable Atorvastatin Loaded Eugenol Enriched PEGylated Cubosomes In-situ Gel for the Intra-pocket Treatment of Periodontitis: Statistical Optimization and Clinical Assessment

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05583643

Enrollment

Registered

2022-10-18

Start date

2021-12-07

Completion date

2022-06-30

Last updated

2022-10-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Keywords

Periodontitis, Non-surgical treatment, Atorvastatin, Phase 1 therapy

Brief summary

Periodontitis is a destructive chronic inflammatory disease characterized by periodontium damage and pocket formation between the tooth and the gingival margin resulting in ultimate tooth loss. Various topical anti-inflammatory drugs were used to treat inflammation in periodontitis. Introducing atorvastatin as a novel remedy for periodontitis treatment necessitates developing a syringeable modified delivery system capable of targeting inflammation within the periodontal pockets.

Interventions

DRUGAtorvastatin Calcium

Atorvastatin loaded into nano particles in-situ gel adjunctive to scaling and debridement

OTHERScaling and debridement only

Scaling and debridement only

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

25 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Systemically healthy patients * Patients with moderate periodontitis

Exclusion criteria

* Pregnant women * Lactating women * Patients with chronic diseases

Design outcomes

Primary

Measure	Time frame
Probing depth	6 weeks
Bleeding index	6 weeks
Plaque index	6 weeks

Secondary

Measure	Time frame
Assessment of transforming growth factor in gingival crevicular fluid	6 weeks

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026