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Phase Angle as a Marker of Muscle Damage, Muscle Fatigue and Inflammation, After Eccentric Exercise

Phase Angle as a Marker of Muscle Damage, Muscle Fatigue and Inflammation, After Eccentric Exercise

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05583500
Enrollment
28
Registered
2022-10-17
Start date
2022-09-19
Completion date
2023-01-10
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Phase Angle

Brief summary

The purpose of this study will be to assess the effectiveness of bioimpedance device (BIA) as a safe, rapid, and non-invasive method of analyzing muscle damage induced by high intensity induced eccentric exercise as an alternative measurement tool against traditional assessment methods. A sample of 28 sedentary subjects will be recruited, all participants will perform an eccentric exercise protocol. Measurements will be done before performing the exercise protocol, immediately after finishing the protocol, 3h after the end of the exercise protocol, 24h after the end of the exercise protocol and 48h after the end of the exercise protocol. The variables analyzed in all subjects will be phase angle, creatinkinase, jumping strength, VAS scale, white blood count cell, quadriceps muscle thickness, Borg scale and anxiety and depression questionnaires.

Interventions

OTHERExperimental: Single group: excentric exercise protocol

Excentric exercise protocol will be performed for all subjets, consisted of 10 sets of 20 repetitions of squats, jumping from a height of 50 cm

Sponsors

Universidad Francisco de Vitoria
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy subjets * Sedentary subjects

Exclusion criteria

* Trained subjects * Subjects with musculoskeletal pathology * Previous Surgeries in the last 6 months * Subjects under pharmacological treatment

Design outcomes

Primary

MeasureTime frameDescription
Phase anglechange from baseline to 72 hoursThe phase angle, which is measured via bioelectrical impedance analysis (BIA), InBody 770 ,is a clinically important bioimpedance parameter used for nutritional assessment and evaluating the risk of various diseases. The phase angle was calculated automatically by the BIA device from these two components according to the following formula: phase angle (°) = (reactance/resistance) × (180°/π).

Secondary

MeasureTime frameDescription
Pain: VASchange from baseline to 72 hoursVisual Analogic Scale. Pain will be measured with a visual analog scale from 0 to 10. 0 points is no pain.
Quadriceps thicknesschange from baseline to 72 hoursQuadriceps muscle thickness will be measures in mm. by an ultrasound device
Creatinkinase (CK concentration)change from baseline to 72 hoursCK concentration will be measure in mg/dl with a portal analyzer (SpotchemTM EZ SP-4430), using test strips.
cellular inflammatory markerschange from baseline to 72 hoursCellular inflammatory markers will be measured with hematology analyzer (Sysmex KX-21N Automed) in 10\^9/L and % White blood count, lymphocytes, neutrophils, monocytes, eosinophils, basophils will be analyzed
Leg powerchange from baseline to 72 hoursLeg power will be assessed using vertical jump test, with Chronojump platform (CHRONOJUMP Boscosystem)

Countries

Spain

Contacts

Primary ContactJorge Buffet García
j.buffet.prof@ufv.es+34619903972

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026