Chronic Obstructive Pulmonary Disease
Conditions
Keywords
Pulmonary diffusing capacity, Reliability, Test-retest
Brief summary
The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) during exercise may be a useful physiological measure of alveolar-capillary reserve in patients with Chronic obstructive pulmonary disease (COPD). The present study investigated the test-retest reliability of DLCO/NO-based metrics.
Detailed description
The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) has recently been standardised and validated for clinical use. It is thus ideal for assessing acute changes in pulmonary diffusing capacity and its components during various physiological manoeuvres. These changes are thought to involve acute changes in pulmonary perfusion and are notably relevant for patients with chronic obstructive pulmonary disease (COPD), in which they may be related to exertional dyspnoea. The aim of the present study is to investigate the effects of acute exercise on pulmonary diffusing capacity, and to determine the day-to-day repeatability of such assessments.
Interventions
DIAGNOSTIC_TESTAcute exercise
The measurement will be repeated within one to seven days.
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Chronic obstructive pulmonary disease (GOLD II + III)
Exclusion criteria
* Known heart disease * Pregnancy * Disease within two weeks prior to inclusion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ICC for VA during exercise | Measured at day 1 and day 2 | ICC for VA with 95% CI during exercise |
| SRD for DM during exercise | Measured at day 1 and day 2 | SRD with 95% CI for DM during exercise |
| SRD for Pulmonary blood volume (Vc) at rest | Measured at day 1 and day 2 | SRD with 95% CI for Vc at rest |
| SRD for Vc during exercise | Measured at day 1 and day 2 | SRD with 95% CI for Vc during exercise |
| SRD for alveolar volume (VA) at rest | Measured at day 1 and day 2 | SRD with 95 % CI for VA at rest |
| SRD for VA during exercise | Measured at day 1 and day 2 | SRD with 95 % CI for VA during exercise |
| Coefficient of Variance (CV) for DLNO at rest | Measured at day 1 and day 2 | CV with a 95% CI at rest |
| CV for DLNO during exercise | Measured at day 1 and day 2 | CV with a 95% CI during exercise |
| CV for DLCOc at rest | Measured at day 1 and day 2 | CV with 95% CI for DLCOc at rest |
| CV for DLCOc during exercise | Measured at day 1 and day 2 | CV with 95% CI for DLCOc during exercise |
| CV for DM at rest | Measured at day 1 and day 2 | CV with 95% CI for DM at rest |
| CV for DM during exercise | Measured at day 1 and day 2 | CV with 95% CI for DM during exercise |
| CV for Vc at rest | Measured at day 1 and day 2 | CV with 95% CI for DM at rest |
| CV for Vc during exercise | Measured at day 1 and day 2 | CV with 95% CI for DM during exercise |
| CV for VA at rest | Measured at day 1 and day 2 | CV with 95% CI for VA at rest |
| CV for VA during exercise | Measured at day 1 and day 2 | CV with 95% CI for VA during exercise |
| Intraclass correlation coefficient (ICC) for DLNO at rest | Measured at day 1 and day 2 | ICC for DLNO with 95% CI at rest |
| Intraclass correlation coefficient (ICC) for DLNO during exercise | Measured at day 1 and day 2 | ICC for DLNO with 95% CI during exercise |
| ICC for DLCOc at rest | Measured at day 1 and day 2 | ICC for DLCOc with 95% CI at rest |
| ICC for DLCOc during exercise | Measured at day 1 and day 2 | ICC for DLCOc with 95% CI during exercise |
| ICC for DM at rest | Measured at day 1 and day 2 | ICC for DM with 95% CI at rest |
| ICC for DM during exercise | Measured at day 1 and day 2 | ICC for DM with 95% CI during exercise |
| ICC for VC at rest | Measured at day 1 and day 2 | ICC for VC with 95% CI at rest |
| ICC for VC during exercise | Measured at day 1 and day 2 | ICC for VC with 95% CI during exercise |
| ICC for VA at rest | Measured at day 1 and day 2 | ICC for VA with 95% CI at rest |
| Rest-to-exercise change in DLNO | Measured at day 1 and day 2 | The physiological change from rest to exercise in DLNO obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Rest-to-exercise change in DLCOc | Measured at day 1 and day 2 | The physiological change from rest to exercise in DLCOc obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Rest-to-exercise change in DM | Measured at day 1 and day 2 | The physiological change from rest to exercise in DM obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Rest-to-exercise change in VC | Measured at day 1 and day 2 | The physiological change from rest to exercise in VC obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Rest-to-exercise change in VA | Measured at day 1 and day 2 | The physiological change from rest to exercise in VA obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Smallest real difference (SRD) for Diffusion capacity for DLNO at rest | Measured at day 1 and day 2 | SRD with 95 % confidence intervals (95% CI) for DLNO at rest |
| SRD for DLNO during exercise | Measured at day 1 and day 2 | SRD with 95% CI for DLNO during exercise |
| SRD for Diffusion capacity for carbon monoxide (DLCOc) at rest | Measured at day 1 and day 2 | SRD with 95% CI for DLCOc at rest |
| SRD for DLCOc during exercise | Measured at day 1 and day 2 | SRD with 95% CI for DLCOc during exercise |
| SRD for membrane diffusing capacity (DM) at rest | Measured at day 1 and day 2 | SRD with 95% CI for DM at rest |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Alveolar volume (VA) during exercise | Measured at day 1 and day 2 | VA during exercise obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Bland Altman Plot - DLNO | Measured at day 1 and day 2 | Bland Altman plot for repeated measures for DLNO |
| Bland Altman Plot - DLCOc | Measured at day 1 and day 2 | Bland Altman plot for repeated measures for DLCOc |
| Bland Altman Plot - DM | Measured at day 1 and day 2 | Bland Altman plot for repeated measures for DM |
| Bland Altman Plot - VC | Measured at day 1 and day 2 | Bland Altman plot for repeated measures for VC |
| Bland Altman Plot - VA | Measured at day 1 and day 2 | Bland Altman plot for repeated measures for VA |
| Breath hold time at rest | Measured at day 1 and day 2 | Breath hold time at rest obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Diffusion capacity for nitric oxide (DLNO) at rest | Measured at day 1 and day 2 | DLNO at rest obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Diffusion capacity for nitric oxide (DLNO) during exercise | Measured at day 1 and day 2 | DLNO during exercise obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Pulmonary blood volume (Vc) during exercise | Measured at day 1 and day 2 | VC during exercise obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Diffusion capacity for carbon monoxide (DLCOc) at rest | Measured at day 1 and day 2 | DLCOc at rest obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Diffusion capacity for carbon monoxide (DLCOc) during exercise | Measured at day 1 and day 2 | DLCOc during exercise obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Membrane diffusing capacity (DM) at rest | Measured at day 1 and day 2 | DM at rest obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Membrane diffusing capacity (DM) during exercise | Measured at day 1 and day 2 | DM during exercise obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Pulmonary blood volume (Vc) at rest | Measured at day 1 and day 2 | VC at rest obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Breath hold time during exercise | Measured at day 1 and day 2 | Breath hold time during exercise obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
| Alveolar volume (VA) at rest | Measured at day 1 and day 2 | VA at rest obtained using the combined DLCO/NO technique with a 5-sec breathhold. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Diffusion capacity for carbon monoxide corrected for hemoglobin | Measured at baseline | DLCOc measured and expressed as mmol/(min\*kPa) and percentage of predicted. |
| Forced Expiratory Volume in 1 second (FEV1) | Measured at baseline | FEV1 measured during dynamic spirometry, and expressed as liter and percentage of predicted. |
| Forced vital capacity (FVC) | Measured at baseline | FVC measured during dynamic spirometry, and expressed as liter and percentage of predicted. |
| FEV1/FVC ratio | Measured at baseline | FEV1/FVC measured during dynamic spirometry, and expressed as liter and percentage of predicted. |
| Residual Volume (RV) | Measured at baseline | RV measured with whole-body plethysmography, and expressed as liter and percentage of predicted. |
| Total Lung Capacity (TLC) | Measured at baseline | TLC measured with whole-body plethysmography, and expressed as liter and percentage of predicted. |
| Peak oxygen consumption (VO2peak) | Measured at baseline | VO2peak test performed on a Monark ergometer bicycle. |
Countries
Denmark
Contacts
Primary ContactRonan Berg, MD
Outcome results
None listed