Restoring Neural Oscillatory Communication in Developmental Dyslexia

Restoring Neural Oscillatory Communication Between Dorsal and Ventral Visual Streams in Developmental Dyslexia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05583136

Enrollment

Registered

2022-10-17

Start date

2021-12-14

Completion date

2024-12-23

Last updated

2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Developmental Dyslexia

Brief summary

Developmental dyslexia (DD) is a multifactorial disorder that hampers the education of about 10% of individuals across cultures and is associated to both phonological and visual deficits. The latter have been linked to a deficit in the magnocellular-dorsal (M-D) visual stream, that has a critical role in guiding the activity of ventral visual stream areas where letters identity is extracted. Here, we will test the efficacy of transcranial alternate current stimulation (tACS) of the M-D stream combined with reading trainings in adult participants with DD, assessing the neurophysiological underpinnings of these new trainings with EEG and fMRI/DTI.

Interventions

DEVICEParietal tACS combined with visuo-attentional training

Parietal tACS combined with visuo-attentional training

DEVICESham (placebo) tACS combined with visuo-attentional training

Sham (placebo) tACS combined with visuo-attentional training

DEVICESham (placebo) tACS combined with phonics training

Sham (placebo) tACS combined with phonics training

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Adult patient (age between 18 and 35) * Official Diagnosis of Developmental Dyslexia (DD) * Normal or corrected-to-normal vision and hearing * Normal motor skills

Exclusion criteria

* Participants that cannot sign the consent form * Participants unable to read or understand and correctly complete the procedures foreseen by the study * Participants with a diagnosis or personal history of epilepsy or patients with a positive family history of epilepsy * Pregnant or breastfeeding patients * Participants with major psychiatric or neurological disorders and/or currently in psychopharmacological treatments. * Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants. * Participants with claustrophobia (only for fMRI)

Design outcomes

Primary

Measure	Time frame	Description
Reading score	Pre-training, 1-7 days post-training, follow-up at 1 and 6 months	Text, word and pseudowords reading score

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026