Aging, Bariatric Surgery, Overweight and Obesity, Sarcopenic Obesity
Conditions
Brief summary
The retrospective cohort study will compare the prevalence of sarcopenia and associated factors between older patients who have undergone bariatric surgery and older patients with obesity without previous bariatric surgery.
Detailed description
The aim of the study is to compare the prevalence of sarcopenia and nutritional status between adults older than 65 years who have previously undergone bariatric surgery and patients with obesity but without previous bariatric surgery. Current sarcopenia will be assessed during a cross-sectional assessment after surgery using the criteria from the European Working Group on Sarcopenia in Older People (EWGSOP).
Interventions
PROCEDUREBariatric surgery
Bariatric surgery
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Signed informed consent * Age 65 years or older * Cohort 1 (exposed): Previous bariatric surgery for obesity at least 1 one year ago * Cohort 2 (unexposed): No previous weight loss surgery
Exclusion criteria
* Current diagnosis of cancer * Advanced organ failure, including chronic kidney disease Stage 5, liver cirrhosis Stage 3, intestinal failure, heart failure stage D, or chronic obstructive pulmonary disease stage 4. * Immobility * Neuromuscular degenerative conditions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The number of older patients with sarcopenia after bariatric surgery compared to non-surgical control patients. | At least one year post surgery | a) Sarcopenia will be classified according to the criteria form the European Working Group on Sarcopenia in Older People revised guidelines (EWGSOP2) based on skeletal muscle mass, muscle strength and physical performance criteria. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 1. Appendicular skeletal muscle mass older of patients after bariatric surgery compared to non-surgical control patients | At least one year post surgery | 1\. Appendicular skeletal muscle mass older of patients after bariatric surgery compared to non-surgical control patients |
| 2. The prevalence of nutrient deficiencies in older patients after bariatric surgery compared to non-surgical control patients. | At least one year post surgery | a. Indices of nutrient deficiencies will include reported dietary intake of protein, zinc, selenium, and blood levels of Vitamin D, zinc, and selenium. |
| 3. Markers of chronic systemic inflammation in older patients after bariatric surgery compared to non-surgical control patients | At least one year post surgery | Inflammatory markers will include CRP, IL-1β, IL-6, IL-8, TNF-α |
Countries
Belgium
Outcome results
None listed