The Effect of Central Sensitization and Neuropathic Pain After Total Knee Arthroplasty

The Effect of Central Sensitization and Neuropathic Pain on Patients Reported Outcomes Following Total Knee Arthroplasty

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05581836

Enrollment

312

Registered

2022-10-17

Start date

2019-01-01

Completion date

2021-12-31

Last updated

2022-10-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuropathic Pain

Brief summary

It has been well known that central sensitization (CS) is a risk factor for inferior outcomes following total knee arthroplasty (TKA). However, there are still insufficient studies on the relationship between CS and neuropathic pain (NP), and the effects of CS and NP on the patient-reported outcome measures (PROMs) of patients who underwent TKA. The purpose of this study was to investigate the relationship between CS and NP and whether CS and NP were associated with PROM in patients undergoing TKA.

Detailed description

A total of 312 patients who underwent primary TKA for end stage knee OA were enrolled. CS was defined as a patient with a score of 40 or higher using central sensitization inventory (CSI). NP was defined as a patient with a score of 12 or more using pain detect questionnaire (PDQ). PROMs were also evaluated based on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score preoperatively and at postoperative 1 year. The patients were divided into 4 groups, group 1 with CS and NP positive, group 2 with only CS positive, group 3 with only NP positive, and group 4 with CS and NP negative, and PROM was compared between the groups.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Inclusion criteria

* Primary knee degenerative osteoarthritis * Patients for total knee arthroplasty over the age of 60 * Patients with 2 year postoperative medical records

Exclusion criteria

* Rheumatoid arthritis * Other inflammatory arthritis * Neuropsychiatric patients * Hepatic insufficiency * Renal insufficiency * Allergy or intolerance to study medications * Patients with an acetylsalicylic acid of IV (angina, congestive heart failure, dementia, cerebrovascular accident) * Chronic opioid use (taking opioids for longer than 3 months) * Alcohol, drug abuser * Narcotics addiction

Design outcomes

Primary

Measure	Time frame	Description
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score	2 years after TKA	Western Ontario and McMaster University Arthritis Index (WOMAC) scale is a validated questionnarie for evaluation of patients who underwent knee operation. The questionnaire consists of 24 tiems, with five pain-related categories (score range 0-20), two stiffness categories (score range 0-8), and 17 physical functional categories (score range 0-68). All items were scored on a 5-point Likert scale (0 = none, 1 = slightly, 2 = moderate, 3 = serious, 4 = extreme). Total score range is 0-96. The lower the score, the better the result.

Countries

South Korea

Outcome results