Factors Associated With Success of NIPPV in ALS Patients

Factors Associated With Success of Non-invasive Positive Pressure Ventilation in Patients With Amyotrophic Lateral Sclerosis: A Retrospective Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05581771

Enrollment

Registered

2022-10-17

Start date

2022-10-18

Completion date

2023-10-04

Last updated

2024-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ALS

Keywords

Noninvasive positive pressure ventilation, Amyotrophic lateral sclerosis, Adherence

Brief summary

This is a retrospective cohort study to assess the factor associated with success of non-invasive positive ventilation in ALS patients.

Detailed description

Patients with ALS who were admitted to a tertiary hospital for initially applying non-invasive positive pressure ventilation (NIPPV). The objective of this study was to investigate factors associated with optimal NIPPV initiation and adherence, and to assess the long-term effects of NIPPV adherence in ALS patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients fulfilling the El Escorial World Federation criteria for probable, or definite ALS * Aged ≥ 19 years * Patients who performed blood gas analysis including venous blood gas and arterial blood gas before NIPPV application.

Exclusion criteria

* Patients who had experience in applying the NIPPV or currently using NIPPV * Patients who applied in outpatient settings * Patients who did not perform blood gas analysis before NIPPV application * Patietns who had a history of asthma or COPD, * Patients who didn't have any record of NIPPV application time

Design outcomes

Primary

Measure	Time frame	Description
Success of NIPPV	through intervention completion, with an average of 10 days	The success of NIPPV application was defined empirically as use of ≥ 2 hours per day and the failure as use of \< 2 hours for a day or conversion to invasive positive pressure ventilation via tracheostomy or refuse to apply NIPPV during hospitalization.

Secondary

Measure	Time frame	Description
Lenght of stay	through intervention completion, with an average of 10 days	The length of stay (LOS) was defined as the interval between admission and hospital discharge, and calculated as the number of midnights between admission and discharge from the hospital.

Countries

South Korea

Outcome results