Biliary Tract Infection Bacterial, Pancreaticoduodenectomy, Surgical Site Infection
Conditions
Brief summary
Preoperative biliary drainage predisposes the bile to be contaminated with bacteria of the duodenum. These bacteria colonizing the bile are a potential source for surgical site infections after pancreaticoduodenectomy and many international guidelines recommend the use of cephalosporines as microbial prophylaxis before surgery. The aim of this study was to assess the incidence of bacteria in bile, their resistance profiles and association to surgical site infections in relation to timing of surgery after preoperative biliary drainage in order to better guide antibiotic use.
Interventions
PROCEDUREPreoperative biliary drainage
Preoperative biliary drainage before pancreaticoduodenectomy. Might be needed if the biliary tract in obstructed and the surgery cannot be scheduled in near future.
Sponsors
Helsinki University Central Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* All patients undergoing pancreaticoduodenectomy between May 23rd 2016 to October 29th 2020
Exclusion criteria
* Patients without intraoperative biliary culture * Patients with unknown date of preoperative biliary culture
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of surgical site infections | 30 days post operatively |
| Prevalence of cephalosporin resistance in intraoperative biliary cultures | At the time of operation |
Countries
Finland
Outcome results
None listed