Aortic Valve Stenosis
Conditions
Brief summary
The objective of the present study is to investigate to hemodynamic profile at rest and during peak exercise of patients with suspected severe aortic stenosis and to compare flow- and pressure changes between high gradient patients and low gradient patients.
Interventions
PROCEDURESimultaneous right and left heart catheterization
Pressure recordings across the aortic valve with simultaneous flow measurements by right heart catheterization, during rest and during supine exercise.
Sponsors
Aarhus University Hospital Skejby
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Patients with suspected severe AS scheduled for evaluation for aortic valve intervention: * LVEF \> 50 % * AVA \< 1.0 cm2 * Symptomatic - at least equivalent to NYHA functional class II
Exclusion criteria
* Congenital heart disease * Severe coronary artery disease (main stem, proximal LAD or 3 vessel disease) * Moderate or severe aortic valve regurgitation * Moderate or severe mitral valve regurgitation or stenosis * Moderate or severe pulmonary valve regurgitation or stenosis * Moderate or severe tricuspid valve regurgitation or stenosis * Severe pulmonary hypertension (tricuspid valve pressure gradient of 60 mmHg) * Right ventricular dysfunction (TAPSE \< 17 mm) * Restrictive cardiomyopathy or cardiac amyloidosis * Constrictive pericarditis * Inability to perform supine bicycle exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pressure and flow relationships across the aortic valve during rest and during supine exercise | 2 hours | Pressure drop across the aortic valve measured invasively. Flow across the valve estimated by right heart catheterization in the absence of aortic valve regurgitation. |
Countries
Denmark
Outcome results
None listed