Multiple Myeloma
Conditions
Brief summary
This prospective study aims to perform intra-individual comparison of the image quality between ultra-low-dose whole-body CT with deep learning reconstruction and conventional low-dose whole-body CT with iterative reconstruction in patients with suspected multiple myeloma.
Interventions
DIAGNOSTIC_TESTnoncontrast-enhanced whole-body CT
noncontrast-enhanced low-dose whole-body CT using dual-source CT scanner using A-tube (75% radiation) and B-tube (25% radiation). * conventional low-dose CT data (A +B tubes, 100% dose) are reconstructed with iterative reconstruction * ultra-low dose CT data (B-tube only, 25% dose) are reconstructed with deep learning commercially available software.
Sponsors
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* signed informed consent * patients with suspected multiple myeloma and scheduled for noncontrast-enhanced low-dose whole-body CT * patients who have no previous history of chemotherapy for multiple myeloma
Exclusion criteria
* patients who do not agree to the protocol * non-Korean patients * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Contrast-to-noise ratio | 3 months after the CT scan | Contrast-to-noise ratio (CNR) of the vertebral body and paraspinal muscle obtained at L1 vertebra level |
Other
| Measure | Time frame | Description |
|---|---|---|
| Signal-to-noise ratio (SNR) | 3 months after the CT scan | Signal-to-noise ratio (SNR) at paraspinal muscle |
| Edge rising distance | 3 months after the CT scan | Edge rising distance at vertebral cortex |
| Subjective overall image quality | 3 months after the CT scan | Subjective overall image quality on four-point scale (1: worst, 4: excellent, representative value is average score) |
| Noise | 3 months after the CT scan | Noise at paraspinal muscle |
| Conspicuity of soft tissue | 3 months after the CT scan | Conspicuity of soft tissue on four-point scale (1: worst, 4: excellent, representative value is average score) |
| Lesion detectability | 3 months after the CT scan | Myeloma lesion detection rate on conventional low-dose CT and ultra-low-dose CT by blinded reviewers |
| Conspicuity of bone structure | 3 months after the CT scan | Conspicuity of bone structure on four-point scale (1: worst, 4: excellent, representative value is average score) |
Countries
South Korea
Contacts
Primary ContactHee-Dong Chae, MD
Backup ContactJeong Hoon Park, BS
Outcome results
None listed