Infertility, Female, Fertility Disorders
Conditions
Keywords
Gonadotrophin-releasing hormone (GnRH) analogues, Ovarian stimulation, Oocyte donation, Progestin-primed ovarian stimulation, Dydrogesterone
Brief summary
Prospective controlled study to assess the reproductive outcomes of OD recipients in which the donors were subjected to the DYG protocol (20mg/day) compared with those subjected to the short protocol with cetrorelix (0.25 mg/day) from Day 7 or since a leading follicle reached 14 mm. The OD cycles were triggered with triptoreline acetate and the trigger criterion was ≥3 follicles of diameter \>18mm.
Interventions
DRUGDydrogesterone
progestin primed ovarian stimulation
Sponsors
Clinica de la Mujer Medicina Reproductiva, Chile
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
21 Years to 30 Years
Inclusion criteria
* Oocyte donors between 21 and 30 years old, with regular menstrual cycles (24-35 d) and a body mass index (BMI) between 18 and 28 kg/m2 without any relevant personal or family history
Exclusion criteria
* AMH less than 3 ng/dL * A positive screening for sexually transmitted diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live Birth Rate per transfer | 40 weeks after ET |
| Clinical pregnancy per transfer | 12 weeks after ET |
| Miscarriage rate | 12 weeks after ET |
Secondary
| Measure | Time frame |
|---|---|
| Number of oocytes retrieved | at time of oocyte retrieval |
| Number of blastocists | 5-6 days after OPU |
| Number of mature oocytes | 1 day after IVF |
| Number of fertilized oocytes | 1 day after IVF |
Outcome results
None listed