• Comparison of Blood Culture Contamination Rates

Comparison of Blood Culture Contamination Rates Between the Use of Povidine Iodine/Alcohol for Skin Antisepsis and the Use of Chlorhexidine/Alcohol (ChloraPrep) for Skin Antisepsis: An Open-label, Randomized Controlled Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05576233

Enrollment

500

Registered

2022-10-12

Start date

2023-10-15

Completion date

2024-12-01

Last updated

2023-02-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Culture Contamination

Keywords

Blood culture contamination, Chloraprep ( alcohol/ chlorhexidine), Povidine/iodine, Topical disinfectants

Brief summary

In this study, blood culture contamination rates will be compared in patients who used povidine/iodine-alcohol and chlorhexidine/alcohol, which were applied before the blood culture was taken by randomized two methods routinely used in this study.

Detailed description

Detection of the pathogen in blood cultures as soon as possible reduces mortality significantly by providing timely initiation of treatment1. However, when skin antisepsis is not performed properly, an increase in the rate of contamination is observed. In this study, it was planned to compare the contamination rate of two antiseptics, povidine iodine/alcohol and Chlorhexidine/alcohol used as skin antisepsis, in the blood culture taken. Full randomization will be applied in the study. Multiples of 3 of the patients to be included in the study will be included in the Chloraprep group, the remaining patients and multiples of 2 will be included in the povidine/iodine group. . According to the number of samples determined for each institution, patients who came to the outpatient clinic during data collection and accepted to participate in the study will be randomly selected.

Interventions

PROCEDUREdisinfection of the surface that the blood culture is taken

lood cultures can be routinely performed with alcohol/povidine-iodine or alcohol/chlorhexidine. The topical disinfectants used in the two applications are the topical disinfectants included in the guidelines and currently applied in our hospital.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

1 Months to 18 Years

Healthy volunteers

Inclusion criteria

* patients who will be hospitalized at SBU Izmir Dr. Patients who are hospitalized in the Pediatric Infection Service of Behçet Uz Pediatrics and Surgery Training and Research Hospital, and who will require blood culture indications will participate in the study If they are willing to

Exclusion criteria

* The patents with central lines will be excluded. * The patient who were transferred from ICU's will be excluded.

Design outcomes

Primary

Measure	Time frame	Description
Blood Contamination	14 days	The primary endpoint of the study was to reduce the rate of contamination in blood cultures.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026