Endothelial Function
Conditions
Brief summary
Purpose: Energy drinks (EDs) are nonalcoholic beverages whose main ingredients are sugar, taurine, and caffeine. Their consumption is rising worldwide, with only few conflicting studies examining their vascular effects in young adults. We evaluated microvascular reactivity (MR) before and after ED in young healthy male volunteers. Methods: Systemic MR was evaluated in the skin of the forearm using laser speckle contrast imaging with acetylcholine (ACh) iontophoresis before, 90 and 180 minutes after the consumption of one can of ED or the same volume of water (control), followed by postocclusive reactive hyperemia (PORH).
Detailed description
Energy drinks (EDs) are nonalcoholic beverages whose main ingredients are sugar, taurine, and caffeine. These products are marketed as boosters of mental and physical performance and are increasingly used in Western societies. Case reports of adverse effects related to ED consumption have been described in healthy young individuals, including coronary artery vasospasm, and myocardial infarction. These data suggest that endothelial dysfunction (EDysf) plays a role in ED cardiovascular effects and have prompted studies with conflicting results. The present study evaluated the microvascular reactivity (MR) after ingestion of one can of ED compared to a control, in young healthy male volunteers.
Interventions
DIETARY_SUPPLEMENTIngestion of the energy drink (Red Bull®)
Ingestion of 250 ml of the energy drink (Red Bull®)
DIETARY_SUPPLEMENTIngestion of mineral water
Ingestion of 250 ml of mineral water (Minalba®)
Sponsors
National Institute of Cardiology, Laranjeiras, Brazil
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy male volunteers with no relevant findings in the medical history
Exclusion criteria
* being a competitive athlete; * being on regular medication; * using illicit drugs; * being allergic to coffee, taurine or any of the components of the selected energy drink; - - * having a body mass index ≥ 30 kg/m2.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endothelium-dependent skin microvascular reactivity | Microvascular reactivity will be evaluated after a 20-minute rest in the supine position in a temperature-controlled room. | Cutaneous microvascular flow measured with laser speckle contrast imaging |
Countries
Brazil
Outcome results
None listed