Executive Function Disorder, Functional Magnetic Resonance Imaging
Conditions
Brief summary
Repetitive transcranial magnetic stimulation (rTMS) is a new neuroelectrophysiological technique developed in recent years. rTMS can affect local and distant cortical function, promote regional reconstruction of cortical function, and has clear curative effect on a variety of neuropsychiatric diseases. Previous study found that rTMS can improve postoperative cognitive function, and there may be a dual biological mechanism. Brain network abnormalities may be the direct cause of postoperative cognitive dysfunction, and neuroinflammation is one of the key molecular mechanisms behind postoperative cognitive dysfunction . rTMS may play a role in the regulation of brain network and inflammatory molecules, and thus play a role in the prevention and treatment of postoperative cognitive dysfunction (POCD).
Detailed description
This study intends to use neuroimaging methods to observe the correlation between neuroinflammation and brain network abnormalities in patients with POCD, and verify the repair effect of rTMS intervention on the pathological changes, so as to provide a theoretical basis for further optimizing the establishment of rTMS localization therapy model for POCD.
Interventions
DEVICErepetitive transcranial magnetic stimulation
The neural navigation system was used to accurately locate the stimulus target.Continuous theta short rapid pulse mode was used. CTBS mode consisted of a slave stimulus delivered every 0.2 seconds (5Hz), and each slave stimulus consisted of three bursts of 50Hz. A single stimulus lasts about 40 seconds and totals 600 pulses.
DEVICEpseudo repetitive transcranial magnetic stimulation
Participant in control group receive pseudo repetitive transcranial magnetic stimulation
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Xuzhou Central Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
45 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Heart valve replacement. * 45 to 75 years old.
Exclusion criteria
* definite cerebral infarction. * failure and decompensation of vital organs * physical metal implants. * severe neuropsychiatric disorders. * less than 9 years of education. * alcohol abuse. * drug dependence.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stroop color words test(SCWT) | Preoperative | The Stroop Color Words test (SCWT) was used to evaluate the dominant inhibition in executive function |
| Trail making test | Preoperative | Trail Making test (TMT) was used to evaluate the set switching in executive function |
| Corsi Block test | Preoperative | The visuospatial working memory of executive function was assessed by the Corsi Block test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional magnetic resonance brain network characteristics | Preoperative | The changes of brain network between intervention group and control group before and after operation were compared. Resting-state fMRI and task-state fMRI were evaluated. |
Countries
China
Contacts
Primary ContactLiwei Wang, Doctor
Backup ContactYangzi Zhu, Doctor
Outcome results
None listed