COVID-19 Respiratory Infection, Dysbiosis, HAI, Microbial Colonization, VAP - Ventilator Associated Pneumonia
Conditions
Keywords
oral microbiota, healthcare-associated infection
Brief summary
The aims of this study were: 1. Observation of dynamics in oral microbiota and its association with the incidence of HAIs and VAP in mechanically ventilated COVID-19 patients in an ICU setting 2. Evaluation of the incidence of HAIs and VAP and their association with oral bacteriobiota in mechanically ventilated COVID-19 patients in an ICU setting 3. Assessment of impact of different oral hygienic procedures on oral microbiota, the incidence of HAI and patients' safety in mechanically ventilated COVID-19 patients in an ICU setting approaches to oral care in an ICU setting Intervention of oral hygienic procedures implemented in study: Patients were divided into 2 groups depending on the oral care procedure: 1. Standard oral procedure (cleaning and moisturizing of oral cavity, suction of excess fluid) 2. Extended oral procedure (cleaning and moisturizing of oral cavity, teeth brushing, suction of excess fluid)
Interventions
PROCEDUREOral Procedure
Interventions included 2 variants of oral hygienic procedures. One was extended of teeth brushing.
Sponsors
University Hospital in Krakow
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Intervention model description
Patients were divided into 2 groups depending on the oral care procedure: 1. Standard oral procedure (cleaning and moisturizing of oral cavity, suction of excess fluid) 2. Extended oral procedure (cleaning and moisturizing of oral cavity, teeth brushing, suction of excess fluid) The procedures were performed twice daily in each patient. The detailed information on these procedures is included in the Appendix 1. The allocation protocol was based on patients' location in the ward. Each room was assigned with one type procedure (standard- even number or extended - uneven number of room), that was permanent during the study period.
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* SARS-CoV-2 infection confirmed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay of nasal and pharyngeal swabs upon hospital admission * Signed consent to participate in the study * Patients admitted to ICU * Intubation due to COVID-19 related pneumonia and acute respiratory distress syndrome (ARDS) within 24 hours preceding study procedures
Exclusion criteria
* No consent to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Healthcare-associated infection | one month | Healthcare-associated infection (HAI) incidence was measured. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Oral cavity assessment | one month | Using The Beck Oral Assessment Scale (BOAS) |
| Frequency of identification of Enterococcus fecalis, Acinetobacter baumannii, Klebsiella pneumoniae. | one month | Frequency of identification of Enterococcus fecalis, Acinetobacter baumannii, Klebsiella pneumoniae in different samples from oral cavity taken from ventilated COVID-19 patients on Intensive Care Unit. |
Countries
Poland
Outcome results
None listed