Metabolic Syndrome
Conditions
Keywords
Myocardial oxygenation
Brief summary
The purpose of this study is to use MRI images using the OS-CMR technique to view the differences in the hearts of healthy volunteers and participants with a condition called Metabolic Syndrome. The objectives of this project are to compare these two groups and to view how health risks, blood test results, and the time since a Metabolic diagnosis can affect heart health.
Detailed description
Myocardial oxygenation changes during vasoactive breathing maneuvers, observed with oxygenation-sensitive cardiac MRI, will be identified and compared between individuals considered healthy and those fitting the criteria of the Metabolic Syndrome.
Interventions
DIAGNOSTIC_TESTCardiac MRI
Participants will undergo an oxygenation-sensitive cardiac MRI and, during the scan, perform a vasoactive breathing maneuver composed of a period of paced hyperventilation followed by a voluntary maximal breath hold.
Sponsors
McGill University Health Centre/Research Institute of the McGill University Health Centre
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Patient Participants: * Age 18-80 * Informed Consent * Diagnosis of MetS (through at least 3 MetS characteristics (abdominal obesity, high triglyceride level, low HDL cholesterol, high systolic blood pressure, and high fasting glucose levels) Healthy Volunteers: * Age 18-80 * No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system * No Smoking
Exclusion criteria
* General MRI contraindications\* * Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy. * Consumption of caffeine (coffee, tea, cocoa, chocolate, energy drink) during the 12 hours prior to the exam
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Global and segmental Myocardial oxygenation reserve (MORE) | Baseline | A t-test will be used to assess the difference in global and segmental MORE, at rest, during hyperventilation, and throughout breath hold, between healthy and volunteers and MetS patients. |
| Relation between Breathing maneuver induced MORE and known MetS risk factors. | Baseline | A linear regression will assess the relation between Breathing maneuver induced MORE and known MetS risk factors, biomarkers, and time since diagnosis. |
Countries
Canada
Contacts
Primary ContactKatherine Lindsay, Master
Backup ContactElizabeth Konidis, Master
Outcome results
None listed