Generalized Anxiety Disorder, Oxygenation Sensitive CMR
Conditions
Brief summary
This study aims to view variations in MRI measurements of the heart and the brain in people with anxiety versus healthy volunteers. The MRI measurements used will be Oxygenation-Sensitive Cardiac MRI (OS-CMR), a recent type of MRI which is safe, fast, and non-invasive.
Detailed description
The investigators will prospectively analyze OS-CMR data from patients with a generalized anxiety disorder from one site. The investigators will observe how an anxiety disorder affects the OS-CMR data. In a follow-up MRI scan, the investigators will look at the OS-CMR of a subgroup who have anxiety disorder and are also undertaking cognitive behavioural therapy to asses how and if this therapy affects the OS-CMR data.
Interventions
DIAGNOSTIC_TESTCardiac MRI
The 4-minute breathing maneuver comprised of 2 minutes of normal breathing and 1-min hyperventilation (rate of 30 breaths per minute) followed by a maximal breath-hold. This technique is used in Oxygenation Sensitive CMR, a type of MRI, and will induce a vasoactive response visible in cardiac and cerebral MRI images
Sponsors
McGill University Health Centre/Research Institute of the McGill University Health Centre
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
Patient population: Age 18-55, * Confirmation of an anxiety disorder as identified by the PSWQ, * No known, current or history, of significant medical conditions that may affect or directly involve the neurological, cardiovascular or respiratory system (except anxiety and depression) * Non-smoker Healthy Volunteers: * Age 18-55 * No known, current or history, of significant medical conditions that may affect or directly involve the neurological, cardiovascular or respiratory system * Non-smoker
Exclusion criteria
* General MRI contraindications: pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, pregnancy * History of significant neurological disease or illness that is not anxiety (e.g. Dementia, stroke) * Hemodynamically unstable conditions * Significant or uncontrolled arrhythmias * Severe pulmonary disease * Recent (\<90 days) myocardial infarction * Recent (\<90 days) surgery or coronary intervention * Consumption of caffeine (caffeinated beverages, coffee, tea, cocoa, chocolate) within 12h of the exam * Use of benzodiazepines or other short-acting anxiety medications (\<1 day)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Signal Intensity | Baseline | Change in signal intensity between the baseline signal intensity and the signal intensity at 30 seconds of breath hold |
Countries
Canada
Contacts
Primary ContactMayssa Moukarzel
Backup ContactElizabeth Konidis, Master
Outcome results
None listed