Skip to content

Clinic and Neurophysiology of Aphasia Treatment

Clinical and Neurophysiological Features of Neurorehabilitation Effects in Cerebrovascular Aphasia

Status
Not yet recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05572385
Acronym
AphasRehab
Enrollment
40
Registered
2022-10-07
Start date
2023-07-01
Completion date
2026-12-31
Last updated
2022-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aphasia, Acquired

Brief summary

In the planned study, clinical and electrophysiological features of aphasia recovery in stroke patients are investigated.

Detailed description

Clinical neurorehabilitation faces a major challenge of functional recovery in aphasia, i.e. guiding the structural and temporal dynamics of reorganization within responsible neural networks. Here, according to current research, relevant neural factors affecting the treatment and thus the functional recovery of aphasia patients after stroke are of interest, highlighting structural as well as functional neuroanatomical features. Of particular interest are not only the functional localization of affected cerebral regions, but more the clinical and neurophysiological patterns which might help to factorize and predict the therapeutic outcome. In the planned study, the clinical and neurophysiological characteristics of the dynamics of language function recovery in relation to the intensity of professional speech therapy (constraint induced aphasia therapie - CIAT) will be recorded in 40 patients with aphasia resulting from a cerebrovascular event. The aim of this study is to test the value of neurophysiological aspects based on electroencephalographic (EEG) parameters such as event-related potentials (N400, P600, theta band activity) for the identification of specific neuronal markers, which in turn support predictive statements for individual therapy planning of logopedic treatment in neurorehabilitation.

Interventions

BEHAVIORALCIAT + Conventional neurorehabilitative therapy

CIAT = Constrained induced aphasia therapy

Sponsors

Klinik Bavaria
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* patients with a cerebrovascular event

Exclusion criteria

* premorbid brain disorder

Design outcomes

Primary

MeasureTime frameDescription
EEG correlates of language reconstitution3-6 months after strokeIdentitification of EEG features (N400, P600, Theta band activity) that correlate with clinical outcome of language reconstitution.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026