Deep Brain Stimulation, Parkinsons Disease
Conditions
Brief summary
By defining the strength and direction of connectivity patterns at rest and during movement across the basal ganglia-thalamocortical (BGTC) network we will characterize the role of individual circuits in motor performance and cognitive function, paving the way for future development of optimization algorithms for DBS that take advantage of this understanding.
Interventions
None listed
Sponsors
University of Minnesota
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Implanted with a DBS system * Existing 7T imagery (either done as standard-of-care or done as part of Noam Harel's study, IRB #1210M22183) * Diagnosed with idiopathic Parkinson's Disease * Minimum age 21 years
Exclusion criteria
* Other significant neurological disorder, as determined by PI * Diagnosis of dementia * Pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Motor association with pathway activation patterns | 6 months post surgery | associate pathway activation patterns with motor (UPDRS-III) outcome obtained during standard of care and research appointments. |
| Cognitive outcome 1 association with pathway activation pattern | 6 months post surgery | associate pathway activation patterns with cognitive outcome obtained during standard of care and research appointments. One primary cognitive outcome measure will be the D-KEFS Letter Fluency test. Another primary cognitive measure will be the Stroop Color Word total score. Secondary measures will include the Beck Depression Inventory (BDI)-II and Apathy Scale total scores. |
| Cognitive outcome 2 association with pathway activation pattern | 6 months post surgery | associate pathway activation patterns with cognitive outcome obtained during standard of care and research appointments. cognitive measure will be the Stroop Color Word total score. |
| Cognitive outcome 3 association with pathway activation pattern | 6 months post surgery | associate pathway activation patterns with cognitive outcome obtained during standard of care and research appointments. cognitive measure will include the Beck Depression Inventory (BDI)-II |
| Cognitive outcome 4 association with pathway activation pattern | 6 months post surgery | associate pathway activation patterns with cognitive outcome obtained during standard of care and research appointments. cognitive measure will include the Apathy Scale total scores. |
Countries
United States
Contacts
CONTACTNiecy Beltz
PRINCIPAL_INVESTIGATORJerrold Vitek, MD, PhD
University of Minnesota
Outcome results
None listed