Subjects With T2D or at Risk of T2D Cohort Follow-up

Descendance Cohort: Follow-up of Subjects With Type 2 Diabetes or at Risk of Type 2 Diabetes Defined by the Existence of the Disease in the Family in Two Successive Generations

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05567692

Acronym

DESCENDANCE

Enrollment

837

Registered

2022-10-05

Start date

2023-02-10

Completion date

2032-10-01

Last updated

2025-02-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus, Type 2

Keywords

Type 2 diabetes ; Risk Prediction ; Prevention

Brief summary

The main objective of this study is to prospectively follow the subjects included in Descendance cohort and to describe the occurrence of type 2 diabetes in non-diabetic subjects, which will allow us to iteratively update the Descendance Type 2 Diabetes risk prediction model.

Detailed description

High risk families will be prospectively follow in order to better understand the risk of transmission of type 2 diabetes from one generation to another. The cohort will also allow us to collect additional data on diabetic patients. The monitoring of the cohort will take place for at least 10 years with a follow-up of all participants every three years. To detect individuals who develop dysglycemia during the study, a glucose tolerance test (GTT) and HbA1c measurement will be conducted.

Interventions

DIAGNOSTIC_TESTOGTT

Oral Glucose Tolerance Test

OTHERHbA1c

HbA1c measurement

OTHERQuestionnaire

Follow-up questionnaire

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Subjects have participated in the Descendance study * Subjets who sign informed consent to participate in the study

Exclusion criteria

* Subjects not enrolled in Descendance study * Subjects refusing to participate * Pregnant or breastfeeding * Subjects in emergency situations, under legal protection or unable to provide informed -consent * Subjects lost to follow-up or died

Design outcomes

Primary

Measure	Time frame	Description
Type 2 diabetes incidence in Descendance population	9years	Presence of type 2 diabetes mellitus, on basis of self-reported (physician diagnosis) or diagnosed by OGTT and HbA1c

Secondary

Measure	Time frame	Description
Provide estimates of prevalence of diabetes and prediabetes in Descendance population	at baseline, 3-, 6- and 9-years follow-up	To estimate the prevalence of undiagnosed diabetes mellitus and pre-diabetes in Descendance population
Study of interactions between risk factors on type 2 diabetes incidence	at baseline, 3-, 6- and 9-years follow-up	Self-administered questionnaire. Descendance specific questionnaire

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026