Inflammatory Bowel Diseases
Conditions
Brief summary
Statins exert numerous pleiotropic effects including anti-inflammatory, antioxidant properties, endothelial function improvement, and immunomodulation independent of their basic lipid-lowering properties.
Interventions
DRUGAtorvastatin 80mg
Atrovastatin is one of the most effective drugs used to reduce intracellular cholesterol synthesis. it exerts numerous pleiotropic effects including anti-inflammatory, antioxidant properties, endothelial function improvement and immunomodulation independent of its basic lipid-lowering properties
DRUGMesalamine
Mesalamine
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Masking description
double-blinded.
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years * Both males and females will be included * Negative pregnancy test and effective contraception.
Exclusion criteria
* Breastfeeding * Significant liver and kidney function abnormalities * Colorectal cancer patients * Patients with severe UC * Patients taking rectal or systemic steroids * Patients taking immunosuppressives or biological therapies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement in health related quality of life | 6 months | HRQL questionnaire will be assessed according to bowel symptoms, emotional symptoms, systemic symptoms, and social symptoms |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes in serum and fecal inflammatory biomarkers | 6 months | The secondary endpoint is estimated by changes in serum IL-18, and fecal calprotectin. |
Countries
Egypt
Outcome results
None listed