Vasculitis
Conditions
Keywords
biomarkers, diagnosis, prognosis
Brief summary
To date, there are no reliable diagnostic blood markers of adult vasculitis. To date, the diagnosis of vasculitis is based on invasive procedure, biopsy of affected tissues potentially at risk of complication . In addition, there are no reliable biomarkers to predict the evolution of vasculitis (relapse, refractory form ...) necessary for the management of patients (type of treatment, duration ..) Prospective study, monocentric (CHU de Tours), non-interventional, aimed at finding diagnostic and prognostic biomarkers (both metabolomic and immunologic) in adult vasculitis patients.
Detailed description
Specimen will be collected at diagnosis, month 1, month 3, and month12 and at the time of a possible relapse. 14 ml of additional blood during a blood puncture made for routine care will be collected at each visit as well as clinical data.
Interventions
OTHERSampling
4 blood sampling per patient and an additional one in case of relapse
Sponsors
University Hospital, Tours
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 16 years * Active vasculitis, new diagnosis or relapse * IgA vasculitis * ANCA vasculitis * Giant cell arteritis
Exclusion criteria
* Person who has objected to the processing of data * Pregnant woman * Patient positive for HIV, HBV, HCV * Treatment in the previous month with corticosteroids, immunosuppressive drugs or biotherapy. * Patient unable to understand the information leaflet * Adult under guardianship or curatorship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cytokine/chemokine/metabolite concentrations | Baseline | Analysis by méthod Luminex |
| percentage of different non-conventional T cell populations | Baseline | study by flow cytometry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cytokine/chemokine/metabolite concentrations | baseline | identify a metabolomic blood profile for the prognosis of vasculitis |
| percentage of different non-conventional T cell populations | baseline | identify an immunological blood profile for the prognosis of vasculitis |
| metabolomic pathway | baseline | Identify a metabolomic pathway involved in the pathophysiology of vasculitis that could be a target for therapy. |
| immunological pathway | baseline | Identify an immunological pathway involved in the pathophysiology of vasculitis that could be a target for therapy. |
Countries
France
Contacts
Primary ContactAlexandra Audemard verger
Outcome results
None listed